公开(公告)号：US20240174696A1

公开(公告)日：2024-05-30

申请号：US18526572

申请日：2023-12-01

Applicant: Genentech, Inc.

Inventor： Steven John MCKERRALL ,  Alice Rose WONG ,  James John CRAWFORD ,  Wendy LEE ,  Kwong Wah LAI ,  Guillaume PELLETIER ,  Stéphanie ROY ,  Dana Krystin WINTER ,  Mikiko OKUMURA ,  Ruth Dorel

IPC: C07D519/00 ,  A61P11/00

CPC classification number: C07D519/00 ,  A61P11/00

Abstract: Disclosed are 2,8-diazaspiro[4.5]decane compounds, including (pyrido[3,4-d]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane compounds, (2,6-naphthyridin-1-yl)-2,8-diazaspiro[4.5]decane compounds, and (1,7-naphthyridin-4-yl)-2,8-diazaspiro[4.5]decane compounds, that are inhibitors of LATS1/2, compositions containing these compounds, and methods for inhibiting LATS1/2 activity.