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![Substituted pyrrolo[2,3-b]pyrazines as serine/threonine kinase inhibitors](/abs-image/US/2016/07/05/US09382257B2/abs.jpg.150x150.jpg)
1.发明授权Substituted pyrrolo[2,3-b]pyrazines as serine/threonine kinase inhibitors 有权取代的吡咯并[2,3-b]吡嗪作为丝氨酸/苏氨酸激酶抑制剂公开(公告)号：US09382257B2
公开(公告)日：2016-07-05
申请号：US14688724
申请日：2015-04-16
Applicant: Genentech, Inc.
Inventor： Daniel Burdick , Huifen Chen , Shumei Wang , Weiru Wang
IPC: A61K31/4985 , C07D231/10 , C07D241/38 , C07D487/04 , A61K45/06
CPC classification number: C07D487/04 , A61K31/4985 , A61K45/06
Abstract: Compounds having the formula I wherein R1 and R2 are as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Abstract translation: 具有式I的化合物，其中R 1和R 2如本文所定义，是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US10787484B2
公开(公告)日：2020-09-29
申请号：US16229226
申请日：2018-12-21
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: C07K7/06 , C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06 , A61K38/00
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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公开(公告)号：US20150218176A1
公开(公告)日：2015-08-06
申请号：US14688724
申请日：2015-04-16
Applicant: Genentech, Inc.
Inventor： Daniel Burdick , Huifen Chen , Shumei Wang , Weiru Wang
IPC: C07D487/04 , A61K45/06 , A61K31/4985
CPC classification number: C07D487/04 , A61K31/4985 , A61K45/06
Abstract: Compounds having the formula I wherein R1 and R2 are as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Abstract translation: 具有式I的化合物，其中R 1和R 2如本文所定义，是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：US11034725B2
公开(公告)日：2021-06-15
申请号：US16883552
申请日：2020-05-26
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: A61K38/00 , C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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公开(公告)号：US20200283478A1
公开(公告)日：2020-09-10
申请号：US16883552
申请日：2020-05-26
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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公开(公告)号：US20190177366A1
公开(公告)日：2019-06-13
申请号：US16229226
申请日：2018-12-21
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, JR. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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