公开(公告)号：US20160090377A1

公开(公告)日：2016-03-31

申请号：US14963653

申请日：2015-12-09

Applicant: Genentech, Inc.

Inventor： Steven P. Govek ,  Mehmet Kahraman ,  Nicholas D. Smith ,  Jeffrey H. Hager ,  Edna Chow Maneval

IPC: C07D405/12 ,  A61K45/06 ,  A61K31/397

CPC classification number: A61K31/397 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K45/06 ,  C07D405/12

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US09873684B2

公开(公告)日：2018-01-23

申请号：US14963658

申请日：2015-12-09

Applicant: Genentech, Inc.

Inventor： Mehmet Kahraman ,  Steven P. Govek ,  Nicholas D. Smith ,  Jeffrey H. Hager ,  Edna Chow Maneval

IPC: C07D405/12 ,  A61K45/06 ,  A61K31/397 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K9/20 ,  A61K9/48

CPC classification number: C07D405/12 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/2054 ,  A61K9/4866 ,  A61K31/397 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K2300/00

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US09475798B2

公开(公告)日：2016-10-25

申请号：US14963653

申请日：2015-12-09

Applicant: Genentech, Inc.

Inventor： Steven P. Govek ,  Mehmet Kahraman ,  Nicholas D. Smith ,  Jeffrey H. Hager ,  Edna Chow Maneval

IPC: C07D405/12 ,  A61K45/06 ,  A61K31/397

CPC classification number: A61K31/397 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K45/06 ,  C07D405/12

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract translation: 本文描述的是雌激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。

公开(公告)号：US20150157606A1

公开(公告)日：2015-06-11

申请号：US14561701

申请日：2014-12-05

Applicant: Genentech, Inc.

Inventor： Edna Chow Maneval ,  Boa Tran H. Truong ,  Isan Chen ,  Jeffrey H. Hager ,  Debasish F. Roychowdhury

IPC: A61K31/416

CPC classification number: A61K31/416

Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.

Abstract translation: 本文描述的是治疗局部晚期或转移性雌激素受体阳性乳腺癌的方法。

公开(公告)号：US20220257592A1

公开(公告)日：2022-08-18

申请号：US17590603

申请日：2022-02-01

Applicant: HOFFMANN-LA ROCHE INC. ,  IGNYTA, INC. ,  GENENTECH, INC.

Inventor： Georgina Meneses-Lorente ,  Edna Chow Maneval ,  Pratik S. Multani ,  Susan Diane Eng ,  Sergio Rene Ley Acosta

IPC: A61K31/496 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer in a patient in need thereof includes administering to the patient a therapeutically effective amount of entrectinib wherein the patient has impaired hepatic function and methods of managing adverse reactions of administration of entrectinib in a patient.

公开(公告)号：US10227334B2

公开(公告)日：2019-03-12

申请号：US15620304

申请日：2017-06-12

Applicant: Genentech, Inc.

Inventor： Mehmet Kahraman ,  Steven P. Govek ,  Nicholas D. Smith ,  Jeffrey H. Hager ,  Edna Chow Maneval

IPC: C07D405/12 ,  A61K31/397 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：US10034860B2

公开(公告)日：2018-07-31

申请号：US15589391

申请日：2017-05-08

Applicant: Genentech, Inc.

Inventor： Edna Chow Maneval ,  Boa Tran H. Troung ,  Isan Chen ,  Jeffrey H. Hager ,  Debasish F. Roychowdhury

IPC: A61K31/416

CPC classification number: A61K31/416

Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.

公开(公告)号：US09855270B2

公开(公告)日：2018-01-02

申请号：US14645578

申请日：2015-03-12

Applicant: Genentech, Inc.

Inventor： Jeffrey J. Hager ,  James D. Joseph ,  Jing Qian ,  Nicholas D. Smith ,  Edna Chow Maneval ,  Debasish F. Roychowdhury ,  Lori Friedman ,  Deepak Sampath

IPC: A61K31/5375 ,  A61K31/416 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4025 ,  A61K31/397 ,  C12Q1/68

CPC classification number: A61K31/5375 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/437 ,  C12Q1/6886 ,  C12Q2600/156

Abstract: Described herein are methods and compositions for treating an ER-related disease condition characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator. Also described herein are methods of treating hormone resistant-estrogen receptor (ER) positive breast cancers characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator.

公开(公告)号：US20170239219A1

公开(公告)日：2017-08-24

申请号：US15589391

申请日：2017-05-08

Applicant: Genentech, Inc.

Inventor： Edna Chow Maneval ,  Boa Tran H. Troung ,  Isan Chen ,  Jeffrey H. Hager ,  Debasish F. Roychowdhury

IPC: A61K31/416

CPC classification number: A61K31/416

Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.

公开(公告)号：US20150258099A1

公开(公告)日：2015-09-17

申请号：US14645578

申请日：2015-03-12

Applicant: Genentech, Inc.

Inventor： Jeffrey J. Hager ,  James D. Joseph ,  Jing Qian ,  Nicholas D. Smith ,  Edna Chow Maneval ,  Debasish F. ROYCHOWDHURY ,  Lori Friedman ,  Deepak Sampath

IPC: A61K31/5375 ,  A61K31/4245 ,  C12Q1/68 ,  A61K31/437 ,  A61K31/4025 ,  A61K31/397 ,  A61K31/416 ,  A61K31/428

CPC classification number: A61K31/5375 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/416 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/437 ,  C12Q1/6886 ,  C12Q2600/156

Abstract: Described herein are methods and compositions for treating an ER-related disease condition characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator. Also described herein are methods of treating hormone resistant-estrogen receptor (ER) positive breast cancers characterized by a mutation in the ESR1 gene by administering an estrogen receptor modulator.

Abstract translation: 本文描述了通过施用雌激素受体调节剂治疗特征在于ESR1基因突变的ER相关疾病状态的方法和组合物。 本文还描述了通过施用雌激素受体调节剂治疗特征在于ESR1基因突变的激素抵抗 - 雌激素受体（ER）阳性乳腺癌的方法。