公开(公告)号：US12215143B2

公开(公告)日：2025-02-04

申请号：US17576344

申请日：2022-01-14

Applicant: Genentech, Inc.

Inventor： Vishva Dixit ,  Marissa Matsumoto ,  Erick Castellanos

IPC: C07K16/18 ,  C12N15/62 ,  G01N33/68

Abstract: The invention provides antibodies that bind mixed-topology polyubiquitin and multispecific anti-polyubiquitin antibodies, and methods of using the same.

公开(公告)号：US20190169278A1

公开(公告)日：2019-06-06

申请号：US16211669

申请日：2018-12-06

Applicant: Genentech, Inc.

Inventor： Vishva Dixit ,  Marissa Matsumoto ,  Erick Castellanos

IPC: C07K16/18 ,  C12N15/62 ,  G01N33/68 ,  A61K47/68

Abstract: The invention provides antibodies having greater avidity for a mixed-topology polyubiquitin than a single-topology polyubiquitin and multispecific anti-polyubiquitin antibodies, and methods of using the same.

公开(公告)号：US20250122272A1

公开(公告)日：2025-04-17

申请号：US18983995

申请日：2024-12-17

Applicant: Genentech, Inc.

Inventor： Vishva Dixit ,  Marissa Matsumoto ,  Erick Castellanos

IPC: C07K16/18 ,  C12N15/62 ,  G01N33/68

Abstract: The invention provides antibodies that bind mixed-topology polyubiquitin and multispecific anti-polyubiquitin antibodies, and methods of using the same.

公开(公告)号：US20220242938A1

公开(公告)日：2022-08-04

申请号：US17576344

申请日：2022-01-14

Applicant: Genentech, Inc.

Inventor： Vishva Dixit ,  Marissa Matsumoto ,  Erick Castellanos

IPC: C07K16/18 ,  G01N33/68 ,  A61K47/68 ,  C12N15/62

Abstract: The invention provides antibodies that bind mixed-topology polyubiquitin and multispecific anti-polyubiquitin antibodies, and methods of using the same.

公开(公告)号：US11274145B2

公开(公告)日：2022-03-15

申请号：US16211669

申请日：2018-12-06

Applicant: Genentech, Inc.

Inventor： Vishva Dixit ,  Marissa Matsumoto ,  Erick Castellanos

IPC: C07K16/18 ,  G01N33/68 ,  A61K47/68 ,  C12N15/62

Abstract: The invention provides antibodies that bind mixed-topology polyubiquitin and multispecific anti-polyubiquitin antibodies, and methods of using the same.