公开(公告)号：US20140314749A1

公开(公告)日：2014-10-23

申请号：US14208523

申请日：2014-03-13

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: C07K16/28 ,  A61K47/48 ,  A61K39/395

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.

Abstract translation: 本发明涉及使用Notch信号传导抑制剂治疗肝癌的方法。 还提供了用于治疗肝癌的组合物和方法。

公开(公告)号：US10208114B2

公开(公告)日：2019-02-19

申请号：US15496516

申请日：2017-04-25

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Christian W. Siebel ,  Erik Huntzicker

IPC: A61K39/395 ,  A61K38/17 ,  A61K38/18 ,  C07K16/28 ,  C07K14/705 ,  C07K14/71 ,  C07K14/475 ,  C07K14/52 ,  C07K14/715 ,  A61K39/00

Abstract: Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.

公开(公告)号：US20170327574A1

公开(公告)日：2017-11-16

申请号：US15496516

申请日：2017-04-25

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Christian W. Siebel ,  Erik Huntzicker

IPC: C07K16/28 ,  A61K39/395 ,  C07K14/71 ,  C07K14/705 ,  A61K39/00 ,  C07K14/715

CPC classification number: C07K16/28 ,  A61K38/177 ,  A61K38/179 ,  A61K38/18 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/475 ,  C07K14/52 ,  C07K14/705 ,  C07K14/71 ,  C07K14/715 ,  C07K16/2863 ,  C07K16/2866 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  Y02A50/463

Abstract: Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.

公开(公告)号：US20180355054A1

公开(公告)日：2018-12-13

申请号：US15964248

申请日：2018-04-27

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/395 ,  C07K16/30 ,  C07K16/22 ,  C07K16/18 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.

公开(公告)号：US09550829B2

公开(公告)日：2017-01-24

申请号：US14208523

申请日：2014-03-13

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/28 ,  A61K47/48 ,  C07K14/475 ,  C07K14/52 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.

Abstract translation: 本发明涉及使用Notch信号传导抑制剂治疗肝癌的方法。 还提供了用于治疗肝癌的组合物和方法。

公开(公告)号：US10266602B2

公开(公告)日：2019-04-23

申请号：US15964248

申请日：2018-04-27

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  A61K39/00

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.

公开(公告)号：US09982058B2

公开(公告)日：2018-05-29

申请号：US15373275

申请日：2016-12-08

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  A61K47/48 ,  C07K14/47 ,  C07K14/475 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.

公开(公告)号：US20170210815A1

公开(公告)日：2017-07-27

申请号：US15373275

申请日：2016-12-08

Applicant: Genentech, Inc.

Inventor： Dorothy French ,  Erik Huntzicker ,  Christian W. Siebel

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

Abstract: The present invention relates to methods of treating liver cancer using a Notch signaling inhibitor. Compositions and methods for the treatment of liver cancers are also provided.