公开(公告)号：US20040234522A1

公开(公告)日：2004-11-25

申请号：US10663158

申请日：2003-09-15

Applicant: Genentech, Inc.

Inventor： Frederic DeSauvage ,  Iqbal Grewal ,  Austin L. Gurney

IPC: A61K039/395 ,  A61K048/00

CPC classification number: C07K14/715 ,  A01K2217/075 ,  A61K38/00 ,  Y02A50/41

Abstract: The present invention relates to methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype, based on the relative expression levels of the gene TCCR, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.

Abstract translation: 本发明涉及用于治疗和诊断免疫相关疾病的方法，包括由主要以Th1或Th2细胞响应于抗原刺激释放的细胞因子介导的那些。 本发明还涉及基于TCCR及其激动剂或拮抗剂的相对表达水平来偏置Th1亚型或Th2亚型中T细胞分化的方法。 本发明还涉及诊断Th1-和Th2介导的疾病的方法。