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    Type I cytokine receptor TCCR
    2.
    发明申请
    Type I cytokine receptor TCCR 审中-公开
    I型细胞因子受体TCCR

    公开(公告)号：US20040234522A1

    公开(公告)日：2004-11-25

    申请号：US10663158

    申请日：2003-09-15

    Applicant: Genentech, Inc.

    Inventor： Frederic DeSauvage ,  Iqbal Grewal ,  Austin L. Gurney

    IPC: A61K039/395 ,  A61K048/00

    CPC classification number: C07K14/715 ,  A01K2217/075 ,  A61K38/00 ,  Y02A50/41

    Abstract: The present invention relates to methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype, based on the relative expression levels of the gene TCCR, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.

    Abstract translation: 本发明涉及用于治疗和诊断免疫相关疾病的方法，包括由主要以Th1或Th2细胞响应于抗原刺激释放的细胞因子介导的那些。 本发明还涉及基于TCCR及其激动剂或拮抗剂的相对表达水平来偏置Th1亚型或Th2亚型中T细胞分化的方法。 本发明还涉及诊断Th1-和Th2介导的疾病的方法。

    Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
    9.
    发明申请
    Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis 审中-公开
    用于诊断和治疗涉及血管生成的疾病的组合物和方法

    公开(公告)号：US20040043927A1

    公开(公告)日：2004-03-04

    申请号：US10081056

    申请日：2002-02-20

    Applicant: GENENTECH, INC.

    Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

    IPC: A61K038/17 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

    CPC classification number: C07K14/515 ,  A61K38/00 ,  C07K2319/00 ,  G01N2800/32

    Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogeniesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    Abstract translation: 公开了用于刺激或抑制包括人在内的哺乳动物的血管生成和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

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