公开(公告)号：US20160143910A1

公开(公告)日：2016-05-26

申请号：US14776586

申请日：2014-03-14

Applicant: Shilpi ARORA ,  Michael Robert COSTA ,  Ted LAU ,  Patrick TROJER ,  GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Shilpi Arora ,  Michael Robert Costa ,  Ted Lau ,  Patrick Trojer ,  Brian K. Albrecht ,  Shane Buker ,  Marie Classon ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Erica L. Jackson ,  Jun Liang ,  Heidi Phillips ,  Peter Sandy ,  Jeffrey Settleman ,  Jean-Philippe Stephan

IPC: A61K31/519 ,  A61K31/437 ,  A61K31/517 ,  A61K45/06 ,  A61K31/337

CPC classification number: A61K31/519 ,  A61K31/337 ,  A61K31/437 ,  A61K31/517 ,  A61K31/555 ,  A61K31/713 ,  A61K33/24 ,  A61K45/06 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531 ,  A61K2300/00

Abstract: Provided herein are methods of treating and/or preventing cancer drug resistance using antagonists of KDM5.

Abstract translation: 本文提供使用KDM5拮抗剂治疗和/或预防癌症耐药性的方法。

公开(公告)号：US20150065781A1

公开(公告)日：2015-03-05

申请号：US14470443

申请日：2014-08-27

Applicant: Genentech, Inc.

Inventor： Carlos BAIS ,  Richard Bourgon ,  Heidi Phillips ,  Thomas Sandmann

IPC: A61K39/395 ,  A61K31/495

CPC classification number: A61K39/3955 ,  A61K31/495 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  A61K2300/00

Abstract: This invention concerns methods of treating a patient diagnosed with glioblastoma comprising administering to said patient a therapy comprising an effective amount of an anti-VEGF antibody and a chemotherapeutic.

公开(公告)号：US20150064178A1

公开(公告)日：2015-03-05

申请号：US14471734

申请日：2014-08-28

Applicant: Genentech, Inc.

Inventor： Carlos BAIS ,  Richard Bourgon ,  Heidi Phillips ,  Thomas Sandmann

IPC: C12Q1/68 ,  A61K39/395 ,  A61K45/06 ,  C07K16/22

CPC classification number: A61K45/06 ,  A61K39/39558 ,  C07K16/22 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2800/52 ,  A61K2300/00

Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients having glioblastomas who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.

Abstract translation: 本发明提供检测一种或多种生物标志物的表达的方法和组合物，用于鉴定和治疗可能对VEGF拮抗剂治疗有反应的成胶质细胞瘤的患者。 本发明还提供用于该方法的试剂盒和制品。

公开(公告)号：US10456470B2

公开(公告)日：2019-10-29

申请号：US14471734

申请日：2014-08-28

Applicant: Genentech, Inc.

Inventor： Carlos Bais ,  Richard Bourgon ,  Heidi Phillips ,  Thomas Sandmann

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/22 ,  C12Q1/68 ,  C12Q1/6886 ,  A61K45/06 ,  G01N33/574

Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients having glioblastomas who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.