公开(公告)号：US20200325248A1

公开(公告)日：2020-10-15

申请号：US16916822

申请日：2020-06-30

Applicant: Genentech, Inc.

Inventor： Xiaocheng CHEN ,  Mark DENNIS ,  Janet JACKMAN ,  James T. KOERBER ,  Mason LU ,  Henry R. MAUN ,  Kathila RAJAPAKSA ,  Saroja RAMANUJAN ,  Tracy STATON ,  Lawren WU ,  Tangsheng YI

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20190367637A1

公开(公告)日：2019-12-05

申请号：US16544421

申请日：2019-08-19

Applicant: Genentech, Inc.

Inventor： Xiaocheng CHEN ,  Mark DENNIS ,  Janet JACKMAN ,  James T. KOERBER ,  Mason LU ,  Henry R. MAUN ,  Kathila RAJAPAKSA ,  Saroja RAMANUJAN ,  Tracy STATON ,  Lawren WU ,  Tangsheng YI

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20180230233A1

公开(公告)日：2018-08-16

申请号：US15893238

申请日：2018-02-09

Applicant: Genentech, Inc.

Inventor： Xiaocheng CHEN ,  Mark DENNIS ,  Janet JACKMAN ,  James T. KOERBER ,  Mason LU ,  Henry R. MAUN ,  Kathila RAJAPAKSA ,  Saroja RAMANUJAN ,  Tracy STATON ,  Lawren WU ,  Tangsheng YI

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20170174733A1

公开(公告)日：2017-06-22

申请号：US15320736

申请日：2015-06-19

Applicant: Genentech, Inc.

Inventor： Robert A. LAZARUS ,  Henry R. MAUN

IPC: C07K14/44 ,  C12N15/10

Abstract: Provided are novel, non-naturally occurring chagasin scaffold proteins derived from chagasin or chagasin-like protease inhibitor proteins. Also provided are libraries of non-naturally occurring chagasin scaffold proteins and methods of using such libraries to generate non-naturally occurring chagasin scaffold proteins that specifically bind to a target ligand. The present invention further provides methods of using non-naturally occurring chagasin protein scaffold that bind to a target ligand, including diagnostic and therapeutic compositions and methods. The invention also provides novel non-naturally occurring chagasin scaffold proteins that specifically bind low density lipoprotein receptor-related protein 6 (LRP6) and novel non-naturally occurring chagasin scaffold proteins that specifically bind vascular endothelial growth factor (VEGF).