公开(公告)号：US20220409725A1

公开(公告)日：2022-12-29

申请号：US17395400

申请日：2021-08-05

申请人： Genentech, Inc.

发明人： Paul CARTER ,  Christoph SPIESS ,  Yiyuan YIN ,  Jianhui ZHOU ,  Wendy SANDOVAL ,  Jacob CORN ,  Michael DILLON

IPC分类号： A61K39/44 ,  C07K16/46 ,  G16B20/50 ,  G16B20/30 ,  A61K39/395

摘要： Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.