公开(公告)号：US20160272588A1

公开(公告)日：2016-09-22

申请号：US15074027

申请日：2016-03-18

Applicant: Genentech, Inc.

Inventor： Robert Blake ,  Paola Di Lello ,  Jake Drummond ,  Christine Johanna Heideker ,  Lorna Kategaya ,  Till Maurer ,  Jeremy M. Murray ,  Chudi Ndubaku ,  Richard Pastor ,  Lionel Rouge ,  Vickie Tsui ,  Ingrid E. Wertz ,  Kebing Yu

IPC: C07D213/73 ,  A61K45/06 ,  C07D409/04 ,  A61K31/4436 ,  C07D213/74 ,  C07D401/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/496 ,  A61K31/4439 ,  A61K31/44 ,  A61K31/5355

CPC classification number: C07D213/73 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5355 ,  A61K45/06 ,  C07D213/74 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04

Abstract: 2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for modulating USP7, and for treating cancer and immune disorders such as inflammation mediated by USP7. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.