公开(公告)号：US20240085404A1

公开(公告)日：2024-03-14

申请号：US18486325

申请日：2023-10-13

Applicant: Genentech, Inc.

Inventor： Chang LIU ,  John Hok Nin LOWE ,  Shan CHUNG

IPC: G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5044 ,  G01N33/6854 ,  G01N2333/70535

Abstract: The present disclosure relates to methods and compositions useful for measuring the transcytosis or recycling of a molecule. In particular, the present disclosure relates to in vitro receptor-dependent transcytosis or recycling assays for evaluating the clearance rates of therapeutic antibody molecules and Fc-fusion proteins in humans and animals.

公开(公告)号：US20250002575A1

公开(公告)日：2025-01-02

申请号：US18658118

申请日：2024-05-08

Applicant: Genentech, Inc.

Inventor： John Hok Nin LOWE ,  Kelly Michele LOYET ,  Elaine MAI ,  Mauricio Silva MAIA ,  Gerald R. NAKAMURA ,  Jack BEVERS, III ,  Hiu Nam CHAN ,  Laetitia D. COMPS-AGRAR ,  Racquel CORPUZ

IPC: C07K16/24 ,  G01N33/68

Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of making and using the same, e.g., for detection of IL-33 in biological samples.