公开(公告)号：US20240085404A1

公开(公告)日：2024-03-14

申请号：US18486325

申请日：2023-10-13

Applicant: Genentech, Inc.

Inventor： Chang LIU ,  John Hok Nin LOWE ,  Shan CHUNG

IPC: G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5044 ,  G01N33/6854 ,  G01N2333/70535

Abstract: The present disclosure relates to methods and compositions useful for measuring the transcytosis or recycling of a molecule. In particular, the present disclosure relates to in vitro receptor-dependent transcytosis or recycling assays for evaluating the clearance rates of therapeutic antibody molecules and Fc-fusion proteins in humans and animals.

公开(公告)号：US20210172932A1

公开(公告)日：2021-06-10

申请号：US17177414

申请日：2021-02-17

Applicant: GENENTECH, INC.

Inventor： Shan CHUNG ,  Van Hong NGUYEN ,  An SONG

IPC: G01N33/50 ,  C07K16/32 ,  G01N33/68

Abstract: The present disclosure relates to methods and compositions useful for measuring the transcytosis of a molecule. In particular, the present disclosure relates to in vitro receptor-dependent transcytosis assays for evaluating the clearance rates of therapeutic antibody molecules and Fc-fusion proteins in humans and animals.