公开(公告)号：US20240331829A1

公开(公告)日：2024-10-03

申请号：US18626741

申请日：2024-04-04

Applicant: Genentech, Inc.

Inventor： Mohammad Jafarnejad ,  Louis Russell Joslyn ,  Iraj Hosseini ,  Saroja Ramanujan

IPC: G16H20/17 ,  G16B15/30

CPC classification number: G16H20/17 ,  G16B15/30

Abstract: The present disclosure relates generally to the field of immunology and oncology, and particularly to systems and methods for use in treating various disorders, such as those associated with cell signaling mediated by cytokines. Some embodiments of the disclosure provide quantitative system pharmacology (QSP) models developed to capture the complex interactions between drug pharmacokinetics and the differential expansion of multiple immune cell subsets across tissues and tumor.