公开(公告)号：US10653779B2

公开(公告)日：2020-05-19

申请号：US14207901

申请日：2014-03-13

Applicant: Genentech, Inc.

Inventor： Sreedhara Alavattam ,  Mary Mallaney ,  Parbir Grewal

IPC: A61K39/395 ,  A61K47/22 ,  C07K16/00 ,  A61K47/18 ,  C07K16/28

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

公开(公告)号：US11596620B2

公开(公告)日：2023-03-07

申请号：US15821470

申请日：2017-11-22

Applicant: Genentech, Inc.

Inventor： Sreedhara Alavattam ,  Mary Mallaney ,  Parbir Grewal

IPC: A61K31/405 ,  A61K39/395 ,  C07K16/28 ,  C07K16/24 ,  G01N33/68 ,  C12Q1/28 ,  A61K39/00

Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.