公开(公告)号：US20210238184A1

公开(公告)日：2021-08-05

申请号：US17105088

申请日：2020-11-25

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Paul Powell Beroza ,  James John Crawford

IPC: C07D487/04

Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R3 have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

公开(公告)号：US20240208919A1

公开(公告)日：2024-06-27

申请号：US18472105

申请日：2023-09-21

Applicant: Genentech, Inc.

Inventor： Jason R. Zbieg ,  Paul Powell Beroza

IPC: C07D307/81 ,  C07D213/74 ,  C07D277/64 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10 ,  C07D491/048 ,  C07F5/02

CPC classification number: C07D307/81 ,  C07D213/74 ,  C07D277/64 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10 ,  C07D491/048 ,  C07F5/025

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US12110276B2

公开(公告)日：2024-10-08

申请号：US18057738

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Russell Tyler Smith ,  Paul Powell Beroza ,  Vishal Anil Verma ,  Bing-Yan Zhu ,  Ramsay Beveridge ,  Lisa Marie Barton ,  Bryan Ka Ip Chan ,  Curtis Colwell ,  Samir Bouayad-Gervais ,  Anwesha Dey ,  Marie Anne Evangelista

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

CPC classification number: C07D231/56 ,  C07D471/04 ,  C07F9/095

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20230054741A1

公开(公告)日：2023-02-23

申请号：US17383422

申请日：2021-07-22

Applicant: Genentech, Inc.

Inventor： Jason R. Zbieg ,  Paul Powell Beroza

IPC: C07D307/81 ,  C07F5/02 ,  C07D491/048 ,  C07D277/64 ,  C07D213/74 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US11787775B2

公开(公告)日：2023-10-17

申请号：US17383422

申请日：2021-07-22

Applicant: Genentech, Inc.

Inventor： Jason R. Zbieg ,  Paul Powell Beroza

IPC: C07D307/81 ,  C07D213/74 ,  C07D277/64 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10 ,  C07D491/048 ,  C07F5/02

CPC classification number: C07D307/81 ,  C07D213/74 ,  C07D277/64 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10 ,  C07D491/048 ,  C07F5/025

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20230202984A1

公开(公告)日：2023-06-29

申请号：US18057738

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Russell Tyler Smith ,  Paul Powell Beroza ,  Vishal Anil Verma ,  Bing-Yan Zhu ,  Ramsay Beveridge ,  Lisa Marie Barton ,  Bryan Ka lp Chan ,  Curtis Colwell ,  Samir Bouayad-Gervais ,  Anwesha Dey ,  Marie Anne Evangelista

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

CPC classification number: C07D231/56 ,  C07D471/04 ,  C07F9/095

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.