公开(公告)号：US20180263996A1

公开(公告)日：2018-09-20

申请号：US15847400

申请日：2017-12-19

Applicant: Genentech, Inc.

Inventor： Olivier RENE ,  Benjamin FAUBER ,  David VESEY ,  Paul WINSHIP ,  Tammy LADDUWAHETTY

IPC: A61K31/541 ,  A61P19/02 ,  A61P11/06 ,  A61P17/06 ,  A61P37/02 ,  A61P29/00

CPC classification number: A61K31/541 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P37/02 ,  C07D279/02 ,  C07D417/10

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein p, s, A, R3 and Re are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20180105516A1

公开(公告)日：2018-04-19

申请号：US15847407

申请日：2017-12-19

Applicant: Genentech, Inc.

Inventor： Benjamin FAUBER ,  Emanuela GANCIA ,  Tammy LADDUWAHETTY ,  David VESEY ,  Paul WINSHIP ,  Olivier RENE

IPC: C07D417/14 ,  A61P17/06 ,  C07D417/10

CPC classification number: C07D417/14 ,  A61K31/541 ,  A61P17/06 ,  A61P19/02 ,  C07D417/10 ,  C07D417/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, Het, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.