公开(公告)号：US20210188775A1

公开(公告)日：2021-06-24

申请号：US17249457

申请日：2021-03-02

Applicant: Genentech, Inc.

Inventor： Christian CUNNINGHAM ,  Paul Powell BEROZA ,  James John CRAWFORD ,  Wendy Lee ,  Olivier RENE ,  Jason Robert ZBIEG ,  Jiangpeng LIAO ,  Tao WANG ,  Chen YU

IPC: C07D213/76 ,  C07C311/08 ,  C07C303/40 ,  C07C235/46 ,  C07C231/14 ,  C07D213/82 ,  C07D209/08 ,  C07D237/24

Abstract: The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20180263996A1

公开(公告)日：2018-09-20

申请号：US15847400

申请日：2017-12-19

Applicant: Genentech, Inc.

Inventor： Olivier RENE ,  Benjamin FAUBER ,  David VESEY ,  Paul WINSHIP ,  Tammy LADDUWAHETTY

IPC: A61K31/541 ,  A61P19/02 ,  A61P11/06 ,  A61P17/06 ,  A61P37/02 ,  A61P29/00

CPC classification number: A61K31/541 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P37/02 ,  C07D279/02 ,  C07D417/10

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein p, s, A, R3 and Re are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20180105516A1

公开(公告)日：2018-04-19

申请号：US15847407

申请日：2017-12-19

Applicant: Genentech, Inc.

Inventor： Benjamin FAUBER ,  Emanuela GANCIA ,  Tammy LADDUWAHETTY ,  David VESEY ,  Paul WINSHIP ,  Olivier RENE

IPC: C07D417/14 ,  A61P17/06 ,  C07D417/10

CPC classification number: C07D417/14 ,  A61K31/541 ,  A61P17/06 ,  A61P19/02 ,  C07D417/10 ,  C07D417/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, Het, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.