公开(公告)号：US20230364020A1

公开(公告)日：2023-11-16

申请号：US18194542

申请日：2023-03-31

Applicant: Genentech, Inc.

Inventor： Purnendu Kumar NAYAK ,  Debby Pei-Shan CHANG ,  Karthikan RAJAGOPAL ,  Jonathan ZARZAR

IPC: A61K9/16 ,  C07K16/32 ,  C07K16/22 ,  C07K16/42

CPC classification number: A61K9/1652 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1647 ,  C07K16/32 ,  C07K16/22 ,  C07K16/4291 ,  A61K9/1694

Abstract: The present invention provides formulations comprising polypeptides and hydroxypropyl methylcellulose acetate succinate (HPMCAS) derivatives. The formulations are stable; for example, during high temperature processing and in possible low pH environments. In addition, the HPMCAS derivatives provide protection to a pH sensitive protein against acidic degradation products from aqueous hydrolysis of poly(lactic-co-glycolic acid) (PLGA) in PLGA-based delivery systems.