公开(公告)号：US10077318B2

公开(公告)日：2018-09-18

申请号：US14851348

申请日：2015-09-11

Applicant: Genentech, Inc.

Inventor： Sunil Bhakta ,  Hans Erickson ,  Jagath R. Junutula ,  Katherine Kozak ,  Rachana Ohri ,  Thomas Pillow

IPC: C07K16/00 ,  C07K16/32 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  A61K51/10 ,  C07K16/40 ,  G01N33/58 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6869 ,  A61K51/10 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/3069 ,  C07K16/3092 ,  C07K16/40 ,  C07K2317/40 ,  C07K2317/73 ,  C07K2317/94 ,  G01N33/582

Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.

公开(公告)号：US20230130874A1

公开(公告)日：2023-04-27

申请号：US17743727

申请日：2022-05-13

Applicant: Genentech, Inc.

Inventor： Sunil Bhakta ,  Hans Erickson ,  Jagath R. Junutula ,  Katherine Kozak ,  Rachana Ohri ,  Thomas Harden Pillow

IPC: C07K16/32 ,  A61K47/68 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  A61K51/10 ,  C07K16/00 ,  C07K16/40 ,  G01N33/58

Abstract: Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.