公开(公告)号：US20190211398A1

公开(公告)日：2019-07-11

申请号：US16105426

申请日：2018-08-20

Applicant: Genentech, Inc.

Inventor： Timothy W. BEHRENS ,  Robert R. GRAHAM

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveneness to lupus therapeutic agents.

公开(公告)号：US20160273044A1

公开(公告)日：2016-09-22

申请号：US15040949

申请日：2016-02-10

Applicant: Genentech, Inc.

Inventor： Timothy W. BEHRENS ,  Robert R. GRAHAM

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.

Abstract translation: 提供鉴定，诊断和预测狼疮的方法，包括狼疮的某些亚型，以及治疗狼疮的方法，包括某些亚群患者。 所提供的方法基于与系统性红斑狼疮（SLE）风险基因座相关的一组等位基因，其包括导致SLE风险的BLK，TNIP1，PRDM1，JAZF1，UHRF1BP1，IL10，IFIH1，CFB，CEC16A，IL12B和SH2B3。 还提供了用于鉴定有效的狼疮治疗剂和预测对狼疮治疗剂的反应性的方法。