公开(公告)号：US20160265056A1

公开(公告)日：2016-09-15

申请号：US15019615

申请日：2016-02-09

Applicant: Genentech, Inc.

Inventor： Timothy W. BEHRENS ,  Kasia OWCZARCZYK ,  Michael J. TOWNSEND

IPC: C12Q1/68 ,  C07K14/705

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  C07K14/70521 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: Biological markers that predict patient responsiveness to B-cell antagonists are provided. Also provided are methods of using such biological markers. In addition, methods for identifying patients suffering from an autoimmune disease, e.g., rheumatoid arthritis, who are not likely to respond to B-cell antagonists are provided, as are methods of treating such patients. Methods for selecting therapeutic agents to treat such patients are also provided.

Abstract translation: 提供了预测患者对B细胞拮抗剂的反应性的生物标志物。 还提供了使用这种生物标记物的方法。 此外，提供了用于鉴定患有自身免疫性疾病例如类风湿性关节炎的患者的方法，所述患者不太可能对B细胞拮抗剂作出反应，以及治疗这些患者的方法。 还提供了用于选择治疗这些患者的治疗剂的方法。

公开(公告)号：US20190211398A1

公开(公告)日：2019-07-11

申请号：US16105426

申请日：2018-08-20

Applicant: Genentech, Inc.

Inventor： Timothy W. BEHRENS ,  Robert R. GRAHAM

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveneness to lupus therapeutic agents.

公开(公告)号：US20160273044A1

公开(公告)日：2016-09-22

申请号：US15040949

申请日：2016-02-10

Applicant: Genentech, Inc.

Inventor： Timothy W. BEHRENS ,  Robert R. GRAHAM

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.

Abstract translation: 提供鉴定，诊断和预测狼疮的方法，包括狼疮的某些亚型，以及治疗狼疮的方法，包括某些亚群患者。 所提供的方法基于与系统性红斑狼疮（SLE）风险基因座相关的一组等位基因，其包括导致SLE风险的BLK，TNIP1，PRDM1，JAZF1，UHRF1BP1，IL10，IFIH1，CFB，CEC16A，IL12B和SH2B3。 还提供了用于鉴定有效的狼疮治疗剂和预测对狼疮治疗剂的反应性的方法。