公开(公告)号：US20190211098A1

公开(公告)日：2019-07-11

申请号：US16227923

申请日：2018-12-20

Applicant: Genentech, Inc.

Inventor： Tushar R. Bhangale ,  Robert R. Graham ,  David V. Hansen ,  Nisha Rathore ,  Ali A. Zarring ,  Jack J. Bevers, III ,  Jianhuan Zhang

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K39/39541 ,  A61K2039/505 ,  A61P25/28 ,  A61P31/22 ,  A61P37/00 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with myeloid cell dysfunction. In particular, provided herein are methods for treatment or diagnosis of a disease associated with myeloid cell dysfunction, such as Alzheimer's Disease (AD) and Herpes Simplex Virus-1 (HSV-1) infection, with an agent specifically binding to Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA), such as an antibody as well as pharmaceutical formulations comprising the same.

公开(公告)号：US10053734B2

公开(公告)日：2018-08-21

申请号：US15040949

申请日：2016-02-10

Applicant: Genentech, Inc.

Inventor： Timothy W. Behrens ,  Robert R. Graham

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Methods of identifying, diagnosing, and prognosing lupus, including certain subphenotypes of lupus, are provided, as well as methods of treating lupus, including certain subpopulations of patients. The methods provided are based on a set of alleles associated with systemic lupus erythematosus (SLE) risk loci including BLK, TNIP1, PRDM1, JAZF1, UHRF1BP1, IL10, IFIH1, CFB, CEC16A, IL12B and SH2B3 that contribute to SLE risk. Also provided are methods for identifying effective lupus therapeutic agents and predicting responsiveness to lupus therapeutic agents.