公开(公告)号：US20190211098A1

公开(公告)日：2019-07-11

申请号：US16227923

申请日：2018-12-20

Applicant: Genentech, Inc.

Inventor： Tushar R. Bhangale ,  Robert R. Graham ,  David V. Hansen ,  Nisha Rathore ,  Ali A. Zarring ,  Jack J. Bevers, III ,  Jianhuan Zhang

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K39/39541 ,  A61K2039/505 ,  A61P25/28 ,  A61P31/22 ,  A61P37/00 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with myeloid cell dysfunction. In particular, provided herein are methods for treatment or diagnosis of a disease associated with myeloid cell dysfunction, such as Alzheimer's Disease (AD) and Herpes Simplex Virus-1 (HSV-1) infection, with an agent specifically binding to Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA), such as an antibody as well as pharmaceutical formulations comprising the same.