公开(公告)号：US20220211797A1

公开(公告)日：2022-07-07

申请号：US17392724

申请日：2021-08-03

Applicant: GENENTECH, INC.

Inventor： Frederick COHEN ,  Lewis J. GAZZARD ,  Vickie Hsiao-Wei TSUI ,  John A. FLYGARE

IPC: A61K38/06 ,  C07K5/09 ,  C07K5/083 ,  C07K5/08 ,  C07K5/087 ,  A61K45/06

Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.

公开(公告)号：US20130172264A1

公开(公告)日：2013-07-04

申请号：US13733244

申请日：2013-01-03

Applicant: GENENTECH, INC.

Inventor： Frederick COHEN ,  Michael KOEHLER ,  Lewis J. GAZZARD ,  Vickie Hsiao-Wei TSUI

IPC: C07K5/09

CPC classification number: A61K38/06 ,  A61K38/00 ,  A61K45/06 ,  C07K5/08 ,  C07K5/0804 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0815

Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1,R2,R3,R4,R5 and R6 are as described herein.

Abstract translation: 可用作治疗恶性肿瘤的治疗剂并具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。

公开(公告)号：US20160102119A1

公开(公告)日：2016-04-14

申请号：US14974140

申请日：2015-12-18

Applicant: GENENTECH, INC.

Inventor： Frederick COHEN ,  Lewis J. GAZZARD ,  Vickie Hsiao-Wei TSUI ,  John A. FLYGARE

IPC: C07K5/087

CPC classification number: A61K38/06 ,  A61K38/00 ,  A61K45/06 ,  C07K5/08 ,  C07K5/0804 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0815

Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.

Abstract translation: 可用作治疗恶性肿瘤的治疗剂的具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。

公开(公告)号：US20140235551A1

公开(公告)日：2014-08-21

申请号：US14269739

申请日：2014-05-05

Applicant: Genentech, Inc.

Inventor： Frederick COHEN ,  Lewis J. GAZZARD ,  Vickie Hsiao-Wei TSUI ,  John A. FLYGARE

IPC: C07K5/08

CPC classification number: A61K38/06 ,  A61K38/00 ,  A61K45/06 ,  C07K5/08 ,  C07K5/0804 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0815

Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.

Abstract translation: 可用作治疗恶性肿瘤的治疗剂并具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。

公开(公告)号：US20170136084A1

公开(公告)日：2017-05-18

申请号：US15420817

申请日：2017-01-31

Applicant: GENENTECH, INC.

Inventor： Frederick COHEN ,  Lewis J. GAZZARD ,  Vickie Hsiao-Wei TSUI ,  John A. FLYGARE

IPC: A61K38/06 ,  A61K45/06

Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.

公开(公告)号：US20140080805A1

公开(公告)日：2014-03-20

申请号：US14088110

申请日：2013-11-22

Applicant: Genentech, Inc.

Inventor： Frederick COHEN ,  Vickie Hsiao-Wei TSUI ,  Cuong LY ,  John A. FLYGARE

IPC: C07D471/04 ,  C07D417/14 ,  C07D417/04

CPC classification number: C07D471/04 ,  C07D417/04 ,  C07D417/14

Abstract: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4′, R5, R6 and R6′ are as described herein.

Abstract translation: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂，其中化合物具有通式I：其中A，Q，X 1，X 2，Y，R 1，R 2，R 3，R 4，R 4'，R 5，R 6 和R6'如本文所述。