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公开(公告)号：US20220211797A1
公开(公告)日：2022-07-07
申请号：US17392724
申请日：2021-08-03
Applicant: GENENTECH, INC.
Inventor： Frederick COHEN , Lewis J. GAZZARD , Vickie Hsiao-Wei TSUI , John A. FLYGARE
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
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公开(公告)号：US20130172264A1
公开(公告)日：2013-07-04
申请号：US13733244
申请日：2013-01-03
Applicant: GENENTECH, INC.
Inventor： Frederick COHEN , Michael KOEHLER , Lewis J. GAZZARD , Vickie Hsiao-Wei TSUI
IPC: C07K5/09
CPC classification number: A61K38/06 , A61K38/00 , A61K45/06 , C07K5/08 , C07K5/0804 , C07K5/0806 , C07K5/0812 , C07K5/0815
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1,R2,R3,R4,R5 and R6 are as described herein.
Abstract translation: 可用作治疗恶性肿瘤的治疗剂并具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。
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![TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER](/abs-image/US/2025/03/13/US20250084096A1/abs.jpg.150x150.jpg)
公开(公告)号：US20250084096A1
公开(公告)日：2025-03-13
申请号：US18913161
申请日：2024-10-11
Applicant: Genentech, Inc.
Inventor： Robert Anthony BLAKE , Peter DRAGOVICH , Lewis J. GAZZARD , Susan KAUFMAN , Tracy KLEINHEINZ , Thomas PILLOW , Steven T. STABEN , Binqing WEI
IPC: C07D495/14 , A61P35/00 , C07D495/16
Abstract: The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
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公开(公告)号：US20160102119A1
公开(公告)日：2016-04-14
申请号：US14974140
申请日：2015-12-18
Applicant: GENENTECH, INC.
Inventor： Frederick COHEN , Lewis J. GAZZARD , Vickie Hsiao-Wei TSUI , John A. FLYGARE
IPC: C07K5/087
CPC classification number: A61K38/06 , A61K38/00 , A61K45/06 , C07K5/08 , C07K5/0804 , C07K5/0806 , C07K5/0812 , C07K5/0815
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
Abstract translation: 可用作治疗恶性肿瘤的治疗剂的具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。
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Patent Agency Ranking
公开(公告)号：US20240383915A1
公开(公告)日：2024-11-21
申请号：US18554438
申请日：2022-04-06
Applicant: Genentech, Inc.
Inventor： Lewis J. GAZZARD , Samantha Alyson GREEN , Elizabeth H. KELLEY , Matthew Leo LANDRY , Sushant MALHOTRA , Benjamin David RAVETZ , Michael SIU , Jack Alexander TERRETT , BinQing WEI , Steven DO , Yun-Xing CHENG , Limin CHENG , Jianfeng XIN , Mingtao HE , Guosheng WU , Yinlei SUN , Cheng SHAO , Aijun LU , Yulai ZHANG
IPC: C07D498/04 , A61K31/553 , A61K45/06 , C07D519/00
Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.
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公开(公告)号：US20170136084A1
公开(公告)日：2017-05-18
申请号：US15420817
申请日：2017-01-31
Applicant: GENENTECH, INC.
Inventor： Frederick COHEN , Lewis J. GAZZARD , Vickie Hsiao-Wei TSUI , John A. FLYGARE
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
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公开(公告)号：US20220281893A1
公开(公告)日：2022-09-08
申请号：US17666350
申请日：2022-02-07
Applicant: Genentech, Inc.
Inventor： Lewis J. GAZZARD , Samantha Alyson GREEN , Matthew Leo LANDRY , Sushant MALHOTRA , Michael SIU , Steven DO , Yun-Xing CHENG , Limin CHENG , Jianfeng XIN , Mingtao HE
IPC: C07D498/22 , C07D519/00 , A61K31/553 , A61K45/06 , A61P35/00
Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.
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![TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3, 2-F][1, 2, 4]TRIAZOLO[4, 3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER](/abs-image/US/2021/07/22/US20210221821A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210221821A1
公开(公告)日：2021-07-22
申请号：US17198240
申请日：2021-03-10
Applicant: Genentech, Inc.
Inventor： Robert Anthony BLAKE , Peter DRAGOVICH , Lewis J. GAZZARD , Susan KAUFMAN , Tracy KLEINHEINZ , Thomas PILLOW , Steven T. STABEN , Binqing WEI
IPC: C07D495/14 , C07D495/16 , A61P35/00
Abstract: The present disclosure relates to compounds and salts thereof that are useful for inhibiting target polypeptides and proteins, in particular, bromodomain (e.g., BRD4) proteins. Also disclosed are pharmaceutical compositions comprising the compounds, or a salt (e.g., a pharmaceutically acceptable salt) thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated diseases or disorders.
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公开(公告)号：US20140235551A1
公开(公告)日：2014-08-21
申请号：US14269739
申请日：2014-05-05
Applicant: Genentech, Inc.
Inventor： Frederick COHEN , Lewis J. GAZZARD , Vickie Hsiao-Wei TSUI , John A. FLYGARE
IPC: C07K5/08
CPC classification number: A61K38/06 , A61K38/00 , A61K45/06 , C07K5/08 , C07K5/0804 , C07K5/0806 , C07K5/0812 , C07K5/0815
Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R1, R2, R3, R4, R5 and R6 are as described herein.
Abstract translation: 可用作治疗恶性肿瘤的治疗剂并具有通式I的IAP的新型抑制剂：其中R1，R2，R3，R4，R5和R6如本文所述。
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