公开(公告)号：US10861584B2

公开(公告)日：2020-12-08

申请号：US15166939

申请日：2016-05-27

Applicant: Genentech, Inc.

Inventor： Vikas K. Sharma ,  Trevor E. Swartz ,  Thomas W. Patapoff

IPC: G16B15/00 ,  G16B35/00 ,  G16C20/60 ,  C07K16/00 ,  G01N33/531

Abstract: Apparatus, systems, computer-readable media, articles of manufacture and methods for selecting an antibody. Apparatus, systems, computer-readable media, articles of manufacture and methods for producing the selected antibody. The selecting may include determining one or more physiochemical characteristics of the antibody. The determining may be based on antibody structural parameters.

公开(公告)号：US11938189B2

公开(公告)日：2024-03-26

申请号：US17386385

申请日：2021-07-27

Applicant: Genentech, Inc.

Inventor： Osigwe Esue ,  Vikas K. Sharma

IPC: A61K39/395 ,  A61K9/00 ,  A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/39591 ,  A61K47/10 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/2845 ,  C07K16/3092 ,  C07K2317/76 ,  C07K2317/94

Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.

公开(公告)号：US09254321B2

公开(公告)日：2016-02-09

申请号：US13722559

申请日：2012-12-20

Applicant: Genentech, Inc.

Inventor： Osigwe Esue ,  Vikas K. Sharma

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K9/00 ,  A61K47/10 ,  A61K9/19

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/39591 ,  A61K47/10 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/2845 ,  C07K16/3092 ,  C07K2317/76 ,  C07K2317/94

Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.

Abstract translation: 本发明涉及某些烷基糖苷组合物在其治疗上有用的制剂中用于预防抗体和其它蛋白质的聚集和氧化的用途。

公开(公告)号：US10188735B2

公开(公告)日：2019-01-29

申请号：US14966363

申请日：2015-12-11

Applicant: Genentech, Inc.

Inventor： Osigwe Esue ,  Vikas K. Sharma

IPC: A61K39/395 ,  A61K47/26 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K9/00 ,  A61K47/10 ,  A61K9/19

Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.

公开(公告)号：US20160199494A1

公开(公告)日：2016-07-14

申请号：US14966363

申请日：2015-12-11

Applicant: Genentech, Inc.

Inventor： Osigwe Esue ,  Vikas K. Sharma

IPC: A61K47/26 ,  C07K16/28 ,  A61K39/395 ,  C07K16/30

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/39591 ,  A61K47/10 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/2845 ,  C07K16/3092 ,  C07K2317/76 ,  C07K2317/94

Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.

Abstract translation: 本发明涉及某些烷基糖苷组合物在其治疗上有用的制剂中用于预防抗体和其它蛋白质的聚集和氧化的用途。

公开(公告)号：US20210353756A1

公开(公告)日：2021-11-18

申请号：US17386385

申请日：2021-07-27

Applicant: Genentech, Inc.

Inventor： Osigwe Esue ,  Vikas K. Sharma

IPC: A61K47/26 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K9/00 ,  A61K47/10 ,  A61K9/19 ,  A61K39/395

Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.

公开(公告)号：US11103584B2

公开(公告)日：2021-08-31

申请号：US16215003

申请日：2018-12-10

Applicant: Genentech, Inc.

Inventor： Osigwe Esue ,  Vikas K. Sharma

IPC: A61K39/395 ,  A61K47/26 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K9/00 ,  A61K47/10 ,  A61K9/19

Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.

公开(公告)号：US20210065843A1

公开(公告)日：2021-03-04

申请号：US17095970

申请日：2020-11-12

Applicant: GENENTECH, INC.

Inventor： Vikas K. Sharma ,  Trevor E. Swartz ,  Thomas W. Patapoff

IPC: G16B15/00 ,  G16B35/00 ,  G16C20/60 ,  C07K16/00 ,  G01N33/531

Abstract: Apparatus, systems, computer-readable media, articles of manufacture and methods for selecting an antibody. Apparatus, systems, computer-readable media, articles of manufacture and methods for producing the selected antibody. The selecting may include determining one or more physiochemical characteristics of the antibody. The determining may be based on antibody structural parameters.

公开(公告)号：US20190216929A1

公开(公告)日：2019-07-18

申请号：US16215003

申请日：2018-12-10

Applicant: Genentech, Inc.

Inventor： Osigwe Esue ,  Vikas K. Sharma

IPC: A61K47/26 ,  C07K16/30 ,  C07K16/28 ,  A61K39/395 ,  A61K9/19 ,  A61K47/10 ,  C07K16/00 ,  A61K9/00

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/39591 ,  A61K47/10 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/2845 ,  C07K16/3092 ,  C07K2317/76 ,  C07K2317/94

Abstract: The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof.