公开(公告)号：US11999787B2

公开(公告)日：2024-06-04

申请号：US17208292

申请日：2021-03-22

申请人： Genentech, Inc.

发明人： Minhong Yan ,  Gu Zhang ,  Nicholas John Agard ,  Danielle Marie Dicara ,  Philip E. Hass ,  Julie Q. Hang ,  Erin L. Christensen ,  Robert Paul Morse ,  Sarah Sanowar ,  Vittal Shivva

IPC分类号： C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/60 ,  A61K47/68 ,  A61P27/02

CPC分类号： C07K16/2863 ,  A61K9/0048 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6849 ,  A61P27/02 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

摘要： The invention provides Tie-2 antibodies and fragments thereof and conjugates and methods of using the same.

公开(公告)号：US20230149509A1

公开(公告)日：2023-05-18

申请号：US17814456

申请日：2022-07-22

申请人： Genentech, Inc. ,  Xencor, Inc.

发明人： Alexander Joachim Paul Ungewickell ,  Vittal Shivva ,  Rajbharan Yadav

IPC分类号： A61K38/17 ,  A61K38/20 ,  A61P35/00

CPC分类号： A61K38/1793 ,  A61K38/2086 ,  A61P35/00

摘要： The present disclosure provides methods of treating cancer by administering a heterodimeric protein comprising a first monomer comprising an IL15 protein-Fc domain fusion and a second monomer comprising an IL15Rα protein-Fc domain fusion.

公开(公告)号：US20240327528A1

公开(公告)日：2024-10-03

申请号：US18609758

申请日：2024-03-19

申请人： Genentech, Inc.

发明人： Minhong Yan ,  Gu Zhang ,  Nicholas John Agard ,  Danielle Marie DiCara ,  Philip E. Hass ,  Julie Q. Hang ,  Erin L. Christensen ,  Robert Paul Morse ,  Sarah Sanowar ,  Vittal Shivva

IPC分类号： C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/60 ,  A61K47/68 ,  A61P27/02

CPC分类号： C07K16/2863 ,  A61K9/0048 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6849 ,  A61P27/02 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

摘要： The invention provides Tie-2 antibodies and fragments thereof and conjugates and methods of using the same.

公开(公告)号：US20240216473A1

公开(公告)日：2024-07-04

申请号：US18431350

申请日：2024-02-02

申请人： Genentech, Inc. ,  Xencor, Inc.

发明人： Shomyseh Sanjabi ,  Vittal Shivva ,  Alexander Joachim Paul Ungewickell ,  Rajbharan Yadav

IPC分类号： A61K38/20 ,  A61K38/17 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K38/2086 ,  A61K38/1793 ,  A61K39/3955 ,  A61P35/00

摘要： The present disclosure provides methods of treating cancer by administering a heterodimeric protein comprising a first monomer comprising an IL15 protein-Fc domain fusion and a second monomer comprising an IL15Rα protein-Fc domain fusion and either increasing the number of NK cells at least 20-fold as compared to the number of NK cells prior to said administration or resulting in the accumulation of NK cells in the subject. The present disclosure also provides methods for inducing the proliferation of NK cells by administering a heterodimeric protein comprising a first monomer comprising an IL15 protein-Fc domain fusion and a second monomer comprising an IL15Rα protein-Fc domain fusion and either increasing the number of NK cells at least 20-fold as compared to the number of NK cells prior to said administration or resulting in the accumulation of NK cells in the subject.