公开(公告)号：US09988400B2

公开(公告)日：2018-06-05

申请号：US15094687

申请日：2016-04-08

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/04 ,  C07D513/10 ,  C07D513/14 ,  C07D519/00

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20180244694A1

公开(公告)日：2018-08-30

申请号：US15962333

申请日：2018-04-25

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/14 ,  C07D519/00 ,  C07D513/04 ,  C07D513/10

CPC classification number: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10647731B2

公开(公告)日：2020-05-12

申请号：US15962333

申请日：2018-04-25

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10280165B2

公开(公告)日：2019-05-07

申请号：US15783373

申请日：2017-10-13

Applicant: Genentech, Inc.

Inventor： Matthew Volgraf ,  Yu Jiang ,  Elisia Villemure ,  Benjamin Sellers ,  Guosheng Wu ,  Aijun Lu

IPC: A61K31/519 ,  C07D471/04 ,  A61P25/00

Abstract: The invention relates to pyridopyrimidinone compounds of formula I or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein, as well as pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US20180127414A1

公开(公告)日：2018-05-10

申请号：US15783373

申请日：2017-10-13

Applicant: Genentech, Inc.

Inventor： Matthew Volgraf ,  Yu Jiang ,  Elisia Villemure ,  Benjamin Sellers ,  Guosheng Wu ,  Aijun Lu

IPC: C07D471/04 ,  A61P25/00

CPC classification number: C07D471/04 ,  A61P25/00

Abstract: The invention relates to pyridopyrimidinone compounds of formula I or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein, as well as pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.