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公开(公告)号：US09988400B2
公开(公告)日：2018-06-05
申请号：US15094687
申请日：2016-04-08
申请人： Genentech, Inc.
发明人： Yu Jiang , Guosheng Wu , Po-Wai Yuen , Elisia Villemure , Jacob Schwarz , Cuong Ly , Benjamin Sellers , Matthew Volgraf
IPC分类号： C07D513/04 , C07D513/10 , C07D513/14 , C07D519/00
CPC分类号： C07D513/14 , C07D513/04 , C07D513/10 , C07D519/00
摘要： The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US10766878B2
公开(公告)日：2020-09-08
申请号：US16247995
申请日：2019-01-15
申请人： Genentech, Inc.
发明人： Baihua Hu , Vishal Verma , Matthew Volgraf , Anthony Estrada , Joseph Lyssikatos
IPC分类号： C07D403/04 , C07D401/04 , C07D231/12 , C07D237/08 , C07D213/61 , C07D231/16 , C07D231/20 , C07D239/26
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
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公开(公告)号：US10647731B2
公开(公告)日：2020-05-12
申请号：US15962333
申请日：2018-04-25
申请人： Genentech, Inc.
发明人： Yu Jiang , Guosheng Wu , Po-Wai Yuen , Elisia Villemure , Jacob Schwarz , Cuong Ly , Benjamin Sellers , Matthew Volgraf
IPC分类号： C07D513/14 , C07D513/04 , C07D513/10 , C07D519/00
摘要： The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US20200308161A1
公开(公告)日：2020-10-01
申请号：US16903020
申请日：2020-06-16
申请人： Genentech, Inc.
发明人： Jack Alexander Terrett , Huifen Chen , Lea Constantineau-Forget , Robin Larouche-Gauthier , Luce Lépissier , Francis Beaumier , Martin Déry , Chantal Grand-Maître , Claudio Sturino , Matthew Volgraf , Elisia Villemure
IPC分类号： C07D413/14 , C07D473/30 , C07D471/04 , A61P29/00 , C07D513/04 , C07D487/04 , A61P25/00 , C07D498/04 , A61K31/427 , A61P23/00 , A61P11/00
摘要： The invention relates to methods of using compounds formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
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公开(公告)号：US10711004B2
公开(公告)日：2020-07-14
申请号：US16558718
申请日：2019-09-03
申请人： Genentech, Inc.
发明人： Huifen Chen , Brian Safina , Daniel Shore , Jack Terrett , Elisia Villemure , Matthew Volgraf , Stuart Ward , Aijun Lu , Robin Larouche-Gauthier , Francis Beaumier , Martin Dery , Lea Constantineau-Forget , Chantal Grand-Maitre , Luce Lepissier
IPC分类号： C07D473/30 , C07D471/04 , C07D487/04 , C07D473/08
摘要： The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
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公开(公告)号：US10695348B2
公开(公告)日：2020-06-30
申请号：US16269973
申请日：2019-02-07
申请人： Genentech, Inc.
发明人： Vishal Verma , Matthew Volgraf , Baihua Hu
IPC分类号： C07D401/02 , C07D401/12 , C07D401/14 , C07D515/04 , A61K31/506 , C07D491/048 , A61P11/00
摘要： The invention provides compounds of formula I: and pharmaceutically acceptable salts thereof where R1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
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公开(公告)号：US20180244694A1
公开(公告)日：2018-08-30
申请号：US15962333
申请日：2018-04-25
申请人： Genentech, Inc.
发明人： Yu Jiang , Guosheng Wu , Po-Wai Yuen , Elisia Villemure , Jacob Schwarz , Cuong Ly , Benjamin Sellers , Matthew Volgraf
IPC分类号： C07D513/14 , C07D519/00 , C07D513/04 , C07D513/10
CPC分类号： C07D513/14 , C07D513/04 , C07D513/10 , C07D519/00
摘要： The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
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公开(公告)号：US11560391B2
公开(公告)日：2023-01-24
申请号：US17150380
申请日：2021-01-15
申请人： Genentech, Inc.
发明人： Jeffrey A. Stafford , James M. Veal , Lynnie Lin Trzoss , Christopher McBride , Richard M. Pastor , Steven Thomas Staben , Craig Stivala , Matthew Volgraf
IPC分类号： C07D498/04
摘要： The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.
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公开(公告)号：US10913742B2
公开(公告)日：2021-02-09
申请号：US16421114
申请日：2019-05-23
申请人： Genentech, Inc.
发明人： Huifen Chen , Daniel Shore , Elisia Villemure , Matthew Volgraf , Baihua Hu , Aijun Lu , Andrew Cridland , Stuart Ward , Francis Beaumier , Martin Dery , Robin Larouche-Gauthier
IPC分类号： C07D487/04 , C07D473/30 , C07D471/04 , C07D513/04 , A61K31/519 , A61P11/06 , C07D498/04
摘要： The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.
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公开(公告)号：US10597383B2
公开(公告)日：2020-03-24
申请号：US16250230
申请日：2019-01-17
申请人： Genentech, Inc.
IPC分类号： C07D401/14 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The invention is concerned with the compounds of formula I: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
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