公开(公告)号：US11279735B2

公开(公告)日：2022-03-22

申请号：US16816969

申请日：2020-03-12

Applicant: Genentech, Inc.

Inventor： Emily J. Hanan ,  Georgette Castanedo ,  Marie Gabrielle Braun ,  Keira Garland ,  Peter Andrew Smith ,  Richard Pastor ,  Paul Gibbons ,  Yunxing Cheng ,  Guosheng Wu ,  Yuhong Fu ,  Po-Wai Yuen

IPC: C07K11/02 ,  A61K38/00

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.