-
公开(公告)号：US20220135528A1
公开(公告)日：2022-05-05
申请号：US17644861
申请日：2021-12-17
Applicant: Genentech, Inc.
Inventor： Michael F.T. Koehler , Peter Andrew Smith , Dana Winter , Boubacar Sow , Claudio Sturino , Guillaume Pelletier , Jonathan Boudreault
IPC: C07D239/42 , A61K31/497 , A61K38/12 , A61K38/14 , C07D239/28 , A61K31/4709 , A61K31/505 , A61K31/351 , A61P31/04 , A61K31/702 , A61K31/5377 , A61K31/545 , A61K31/165 , A61K45/06
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US11208387B2
公开(公告)日：2021-12-28
申请号：US16884679
申请日：2020-05-27
Applicant: Genentech, Inc.
Inventor： Michael F. T. Koehler , Peter Andrew Smith , Dana Winter , Boubacar Sow , Claudio Sturino , Guillaume Pelletier , Jonathan Boudreault
IPC: A61K31/505 , C07D239/28 , C07D239/42 , A61K45/06 , A61P31/04 , A61K31/702 , A61K31/4709 , A61K38/14 , A61K31/497 , A61K31/165 , A61K31/351 , A61K38/12 , A61K31/5377 , A61K31/545
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US10351595B2
公开(公告)日：2019-07-16
申请号：US15312614
申请日：2015-05-19
Applicant: RQX PHARMACEUTICALS, INC. , GENENTECH, INC.
Inventor： Tucker Curran Roberts , Peter Andrew Smith , Robert I. Higuchi , Prasuna Paraselli , Philippe Bergeron , Michael F. T. Koehler , Huiyong Hu , Jacob Bradley Schwarz , Cuong Ly , James John Crawford
IPC: A61K38/00 , C07K5/103 , C07K7/06 , C07K7/08 , C07K5/02 , C07K5/087 , C07K5/09 , C07K5/11 , A61K45/06 , A61K31/395 , A61K31/407 , A61K31/4196 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/545 , A61K31/546 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/083 , A61K38/12
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US10392422B2
公开(公告)日：2019-08-27
申请号：US15312614
申请日：2015-05-19
Applicant: RQX PHARMACEUTICALS, INC. , GENENTECH, INC.
Inventor： Tucker Curran Roberts , Peter Andrew Smith , Robert I. Higuchi , Prasuna Paraselli , Philippe Bergeron , Michael F. T. Koehler , Huiyong Hu , Jacob Bradley Schwarz , Cuong Ly , James John Crawford
IPC: A61K38/00 , C07K5/103 , C07K7/06 , C07K7/08 , C07K5/02 , C07K5/087 , C07K5/09 , C07K5/11 , A61K45/06 , A61K31/395 , A61K31/407 , A61K31/4196 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/545 , A61K31/546 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/083 , A61K38/12
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
Patent Agency Ranking
公开(公告)号：US20230133817A1
公开(公告)日：2023-05-04
申请号：US18063173
申请日：2022-12-08
Applicant: RQX Pharmaceuticals, Inc. , Genentech, Inc.
Inventor： Yongsheng Chen , Peter Andrew Smith , Tuker Curran Roberts , Robert I. Higuchi , Prasuna Paraselli , Michael F.T Koehler , Jacob Bradley Schwarz , James John Crawford , Cuong Q. Ly , Emily J. Hanan , Huiyong Hu , Zhiyong Yu
IPC: C07D245/04 , C07K5/02 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , A61K31/496 , A61K31/546 , C07K5/087 , C07K5/103 , C07K5/11 , C07K7/06 , C07K7/08 , C07K5/113 , C07K9/00 , C07K5/117 , A61K31/395 , A61K31/431 , A61K31/407 , A61K31/43 , A61K31/4196 , A61K31/545 , C07K5/09 , A61P31/04 , A61K9/00
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US11279735B2
公开(公告)日：2022-03-22
申请号：US16816969
申请日：2020-03-12
Applicant: Genentech, Inc.
Inventor： Emily J. Hanan , Georgette Castanedo , Marie Gabrielle Braun , Keira Garland , Peter Andrew Smith , Richard Pastor , Paul Gibbons , Yunxing Cheng , Guosheng Wu , Yuhong Fu , Po-Wai Yuen
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US11072635B2
公开(公告)日：2021-07-27
申请号：US15777509
申请日：2016-11-21
Applicant: RQX PHARMACEUTICALS, INC. , GENENTECH, INC.
Inventor： Yongsheng Chen , Peter Andrew Smith , Tucker Curran Roberts , Robert I. Higuchi , Prasuna Paraselli , Michael F. T. Koehler , Jacob Bradley Schwarz , James John Crawford , Cuong Q. Ly , Huiyong Hu , Zhiyong Yu
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US20200377463A1
公开(公告)日：2020-12-03
申请号：US16884679
申请日：2020-05-27
Applicant: Genentech, Inc.
Inventor： Michael F.T. Koehler , Peter Andrew Smith , Dana Winter , Boubacar Sow , Claudio Sturino , Guillaume Pelletier , Jonathan Boudreault
IPC: C07D239/42 , A61K45/06 , A61K31/505 , A61P31/04 , A61K31/702 , A61K31/4709 , A61K31/545 , A61K38/14 , A61K31/497 , A61K31/165 , A61K31/351 , A61K38/12 , A61K31/5377 , C07D239/28
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
公开(公告)号：US20230133667A1
公开(公告)日：2023-05-04
申请号：US18047624
申请日：2022-10-18
Applicant: RQx Pharmaceuticals, Inc. , Genentech, Inc.
Inventor： Peter Andrew Smith , Tucker Curran Roberts , Robert I. Higuchi , Prasuna Paraselli , Michael F. T. Koehler , Jacob Bradley Schwarz , James John Crawford , Cuong Q. Ly , Emily J. Hanan , Huiyong Hu , Yongsheng Chen , Zhiyong Yu , Paul Colin Michael Winship , Calum MacCleod , Toby Blench
IPC: C07K5/11 , A61P31/04 , A61K9/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/083 , C07K5/097 , C07K5/107 , C07K7/06
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.03 seconds)
