公开(公告)号：US20200231921A1

公开(公告)日：2020-07-23

申请号：US16753026

申请日：2018-10-03

Applicant: General Electric Company

Inventor： Chengkun Zhang ,  Kashan A. Shaikh ,  Weston B. Griffin ,  Reginald Donovan Smith

IPC: C12M1/00 ,  B01D61/14 ,  B01D61/18 ,  B01D69/10 ,  B01D69/02 ,  A61M1/34

Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.