公开(公告)号：US20030158379A1

公开(公告)日：2003-08-21

申请号：US09994177

申请日：2001-11-26

申请人： Genetics Institute, Inc.

发明人： Anthony J. Celeste ,  Beth L. Murray

IPC分类号： C07K014/51

CPC分类号： C07K14/495 ,  A61K38/00 ,  C07K14/51 ,  C07K2319/00

摘要： Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.

摘要翻译： 公开了纯化的BMP-16蛋白质及其生产方法。 还公开了编码BMP-16蛋白质的DNA分子。 蛋白质可以用于治疗伤口愈合和相关组织修复中的骨，软骨，其他结缔组织缺陷和障碍，包括腱，韧带和半月板，以及用于治疗包括表皮的组织的病症和缺陷， 神经，肌肉，包括心肌和其他组织和伤口，以及诸如肝，肺，心脏，胰腺和肾组织的器官。 蛋白质也可用于诱导未分化胚胎和干细胞的生长和/或分化。