公开(公告)号：US20170088588A1

公开(公告)日：2017-03-30

申请号：US14924861

申请日：2015-10-28

Applicant: Genia Technologies, Inc.

Inventor： Michael DORWART ,  Daniel KORENBLUM

IPC: C07K14/31 ,  C12Q1/68

CPC classification number: C07K14/31 ,  C12Q1/6869 ,  C12Q2565/631

Abstract: Described herein are variants of alpha-hemolysin having at least one mutation selected from T12R, T12K, N17R, N17K or combinations of T12 and N17 mutations. The variants in some embodiments may further comprise H144A. The α-hemolysin variants have a decreased time to thread.

公开(公告)号：US20190119745A1

公开(公告)日：2019-04-25

申请号：US16238874

申请日：2019-01-03

Applicant: GENIA TECHNOLOGIES, INC.

Inventor： Timothy Kellogg CRAIG ,  Cynthia Ann CECH ,  Michael DORWART ,  Liv Elisabeth JENSEN ,  Marshall Winston PORTER ,  Christos TZITZILONIS ,  Alexander Hyun-min YANG

IPC: C12Q1/6869 ,  C07K14/31

CPC classification number: C12Q1/6869 ,  C07K14/31 ,  C12Q2565/607 ,  C12Q2565/631

Abstract: Described herein are engineered alpha-hemolysin subunits having mutated oligomerization domains for assembling into heptameric nanopores in lipid bilayers.

公开(公告)号：US20170088890A1

公开(公告)日：2017-03-30

申请号：US15274770

申请日：2016-09-23

Applicant: Genia Technologies, Inc.

Inventor： Timothy Kellogg CRAIG ,  Cynthia Ann CECH ,  Michael DORWART ,  Liv Elisabeth JENSEN ,  Marshall Winston PORTER ,  Christos TZITZILONIS ,  Alexander Hyun-min YANG

IPC: C12Q1/68 ,  C07K14/31

CPC classification number: C12Q1/6869 ,  C07K14/31 ,  C12Q2565/607 ,  C12Q2565/631

Abstract: Described herein are engineered alpha-hemolysin subunits having mutated oligomerization domains for assembling into heptameric nanopores in lipid bilayers.