公开(公告)号：US20230263902A1

公开(公告)日：2023-08-24

申请号：US18010783

申请日：2021-06-29

Applicant: Genmab A/S

Inventor： Reshma A. RANGWALA

IPC: A61K47/68 ,  A61P35/00 ,  A61K9/00

CPC classification number: A61K47/6803 ,  A61K47/6849 ,  A61P35/00 ,  A61K9/0019

Abstract: The invention provides methods and compositions for treating cancer, such as advanced cervical cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., advanced cervical cancer).

公开(公告)号：US20240252673A1

公开(公告)日：2024-08-01

申请号：US18451780

申请日：2023-08-17

Applicant: Genmab A/S

Inventor： Reshma A. RANGWALA ,  Steen LISBY

IPC: A61K47/68 ,  A61K9/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  C07K16/32 ,  A61K39/00

CPC classification number: A61K47/6869 ,  A61K9/0019 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6811 ,  A61P35/00 ,  A61P35/04 ,  C07K16/32 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/565

Abstract: The invention provides methods and compositions for treating cancer, such as advanced cervical cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., advanced cervical cancer).

公开(公告)号：US20210308208A1

公开(公告)日：2021-10-07

申请号：US17268387

申请日：2019-08-14

Applicant: Genmab A/S

Inventor： Reshma A. RANGWALA ,  Esther C.W. BREIJ ,  Sandra VERPLOEGEN ,  Bart DE GOEIJ ,  Oyewale O. ABIDOYE ,  Leonardo V. NICACIO ,  Stephen C. ALLEY

IPC: A61K38/07 ,  A61K47/68 ,  A61K47/65 ,  A61K47/54 ,  A61P35/00

Abstract: The invention provides methods and compositions for treating cancer, such as ovarian cancer, peritoneal cancer, and fallopian tube cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., ovarian cancer, peritoneal cancer, and fallopian tube cancer).