公开(公告)号：US20230212301A1

公开(公告)日：2023-07-06

申请号：US18055362

申请日：2022-11-14

申请人： Genmab B.V.

发明人： Andreea Ioan ,  Frank Beurskens ,  Rob N. de Jong ,  Janine Schuurman ,  Esther C. W. Breij ,  Isil Altintas ,  Pauline L. de Goeje ,  David Satijn ,  Peter Boross ,  Ugur Sahin ,  Friederike Gieseke ,  Alexander Muik ,  Kristina Schödel

IPC分类号： C07K16/28 ,  C07K16/42 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/4208 ,  A61K2039/505

摘要： The present invention relates to antibodies capable of binding to human CD27 and to variants thereof comprising a modified Fc region comprising one or more mutations that enhances the Fc-Fc interaction of the antibody. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.