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    IP-10 antibody dosage escalation regimens
    6.
    发明授权
    IP-10 antibody dosage escalation regimens 有权
    IP-10抗体剂量升高方案

    公开(公告)号：US09429581B2

    公开(公告)日：2016-08-30

    申请号：US14055238

    申请日：2013-10-16

    申请人： BRISTOL-MYERS SQUIBB COMPANY

    发明人： Allison Y. Luo ,  Wendy L. Trigona ,  Jinshan Shen ,  Li-An Xu ,  Yan Zhang ,  Bruce Stouffer ,  Haibin Chen ,  Haichun Huang ,  Xiaolu Tao ,  Catherine Brockus

    IPC分类号： G01N33/68 ,  C07K16/24 ,  C07K16/42 ,  A61K39/395 ,  A61K39/00

    CPC分类号： G01N33/686 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/4208 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/90

    摘要： In certain embodiments, the present invention provides a method of treating an Interferon gamma inducible protein 10 (IP-10)-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IP-10 antibody; (b) detecting the level of the anti-IP-10 antibody in a sample of the subject; and (c) if the level of the anti-IP-10 antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IP-10 antibody in the subject such that the IP-10 related disease in the subject is treated. In certain embodiments, the present invention provides an isolated monoclonal anti-idiotypic antibody, or an antigen binding portion thereof, which binds to the anti-IP-10 antibody MDX-1100.

    摘要翻译： 在某些实施方案中，本发明提供了治疗受试者中的干扰素γ诱导蛋白10（IP-10）相关疾病的方法，其包括：（a）向受试者施用预定剂量的抗-IP-10抗体 ; （b）检测受试者样品中抗-IP-10抗体的水平; 和（c）如果来自步骤（b）的抗-IP-10抗体的水平低于临界暴露水平，则增加受试者中抗-IP-10抗体的剂量使得IP-10相关疾病在 该主题得到对待。 在某些实施方案中，本发明提供了与抗-IP-10抗体MDX-1100结合的分离的单克隆抗独特型抗体或其抗原结合部分。

    Genus-Wide Chlamydial Peptide Vaccine Antigens
    8.
    发明申请
    Genus-Wide Chlamydial Peptide Vaccine Antigens 有权
    广谱衣原体肽疫苗抗原

    公开(公告)号：US20110236484A1

    公开(公告)日：2011-09-29

    申请号：US13120071

    申请日：2009-09-21

    申请人： Judith Whittum-Hudson ,  Alan P. Hudson

    发明人： Judith Whittum-Hudson ,  Alan P. Hudson

    IPC分类号： A61K9/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K7/64 ,  A61K39/00 ,  A61K39/12 ,  C07H21/00 ,  C12N15/63 ,  A61P37/04 ,  A61P31/04

    CPC分类号： C07K16/125 ,  A61K39/118 ,  C07K7/06 ,  C07K7/08 ,  C07K16/4208 ,  G01N33/56927 ,  G01N2469/20

    摘要： Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which act as molecular mimics of GLXA are also disclosed used as immunogens to induce broadly reactive genus-specific anti-chlamydial antibodies. These peptides and immunogenic DNA encoding the mAb2-like peptides, microparticle or nanoparticle formulations and other formulations of these peptides are disclosed as are methods for immunizing subjects to obtain genus-specific anti-chlamydial antibodies and to treat or prevent Chlamydia-associated or induced rheumatoid arthritis.

    摘要翻译： 公开了从由衣原体糖脂外源抗原（GLXA）的单克隆抗体结合并因此模拟该抗原的随机文库产生的肽。 对应于作为GLXA分子模拟物的抗GLXA抗体（Ab1）特异的抗独特型抗体（mAb2）的抗原结合区的肽也被公开用作免疫原，以诱导广泛活性的特异性抗衣原体抗体 。 公开了编码mAb2样肽，微粒或纳米颗粒制剂和这些肽的其它制剂的这些肽和免疫原性DNA，用于免疫受试者以获得属特异性抗衣原体抗体并治疗或预防衣原体相关或诱导的类风湿病的方法 关节炎。

    IMMUNOASSAY DEVICE AND METHOD
    10.
    发明申请
    IMMUNOASSAY DEVICE AND METHOD 审中-公开
    免疫设备和方法

    公开(公告)号：US20090246795A1

    公开(公告)日：2009-10-01

    申请号：US12095082

    申请日：2006-12-21

    申请人： Yoko Hayashi ,  Osamu Takehiro

    发明人： Yoko Hayashi ,  Osamu Takehiro

    IPC分类号： G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/558 ,  C07K16/4208 ,  C07K2317/54

    摘要： An immunoassay device capable of assaying amount of an antigen by allowing a labeled antibody to specifically bind to a antigen analyte in a sample and assaying a label of a bound product, an interior of a single device has four regions comprises: (1) a first region where the antigen in the sample reacts with a first antibody that is the labeled antibody capable of specifically binding to the antigen, (2) a second region where first antibody that has not bound to the antigen reacts with a second biotin- or avidin-bound antibody, (3) a third region where, depending on whether the second antibody is biotin-bound antibody or avidin-bound antibody, either avidin or biotin is immobilized by immobilization means so as to be unable to move to the fourth region, and the second antibody is captured by the immobilized avidin or biotin, and (4) a fourth region where the label of the first antibody that has bound to the antigen is detected, being constructed in such a way that a solution can move sequentially through each region, the first antibody, which is the labeled antibody such that an antibody component is an F(ab′) fragment or reduced IgG, the F(ab′) fragment or reduced IgG being bound with the label in a predetermined proportion, is included in the first region or an adjacent region, and the second antibody is a biotin- or avidin-bound antibody, being of anti-idiotype antibody against the first antibody and a type that cannot bind to the bound product of the antigen and first antibody, and is included in the second region or an adjacent region.

    摘要翻译： 一种免疫测定装置，其能够通过使标记的抗体特异性结合样品中的抗原分析物并测定结合产物的标记物来测定抗原量，单个装置的内部具有四个区域：（1）第一 样品中的抗原与能够特异性结合抗原的标记抗体的第一抗体反应的区域，（2）第二区域，其中未结合抗原的第一抗体与第二生物素或抗生物素蛋白 - 结合抗体，（3）第三区域，其中取决于第二抗体是否是生物素结合的抗体或抗生物素蛋白结合的抗体，通过固定装置将抗生物素蛋白或生物素固定以使其不能移动到第四区域，以及 第二抗体被固定化的抗生物素蛋白或生物素捕获，和（4）检测到与抗原结合的第一抗体的标记的第四区域以使溶液能够移动的方式构建 依次通过每个区域，即作为标记抗体的第一抗体，使得抗体成分为F（ab'）片段或还原的IgG，F（ab'）片段或还原IgG与标记以预定比例结合 被包括在第一区域或相邻区域中，第二抗体是生物素或抗生物素蛋白结合的抗体，其是针对第一抗体的抗独特型抗体，以及不能结合抗原结合产物的类型和 第一抗体，并且包括在第二区域或相邻区域中。