公开(公告)号：US20210009983A1

公开(公告)日：2021-01-14

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Donald E. TRIMBUR ,  Andreas W. SCHIRMER ,  Cindy CHANG ,  Behnaz BEHROUZIAN ,  Jessica WINGER

IPC: C12N9/00 ,  C07K14/245 ,  C12P7/64

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.