公开(公告)号：US20250084387A1

公开(公告)日：2025-03-13

申请号：US18580585

申请日：2022-08-29

Applicant: Genomatica, Inc.

Inventor： Amit Mahendra Shah ,  Justin Robert Colquitt ,  Michael Gregory Napolitano ,  Nathan Schmidt ,  Pichet Praveschotinunt ,  Joseph Roy Warner

IPC: C12N9/02 ,  C12N1/26 ,  C12N15/70 ,  C12P7/18

Abstract: The disclosure provides polypeptides and encoding nucleic acids of engineered formate dehydrogenases. The disclosure also provides cells expressing an engineered formate dehydrogenase. The disclosure further provides methods for producing a bioderived compound comprising culturing cells expressing an engineered formate dehydrogenase. Where the engineered formate dehydrogenase is capable of catalyzing a conversion.

公开(公告)号：US20220348890A1

公开(公告)日：2022-11-03

申请号：US17605499

申请日：2020-04-24

Applicant: Genomatica, Inc.

Inventor： Amit M. Shah ,  Harish Nagarajan ,  Joseph Roy Warner ,  Russell Scott Komor

IPC: C12N9/10 ,  C12P13/00

Abstract: Disclosed are transaminase (TA) enzymes and nucleic acids encoding them. In some cases, the transaminase enzymes are non-natural, engineered transaminases. Also disclosed are biosynthetic methods and engineered microorganisms that enhance or improve the biosynthesis of 6-aminocaproate, hexamethylenediamine, caproic acid, caprolactone, or caprolactam. The engineered microorganisms include exogenous TA and in some cases engineered TA.