公开(公告)号：US11008597B2

公开(公告)日：2021-05-18

申请号：US15301754

申请日：2015-04-10

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Andreas W. Schirmer ,  Myong Ko ,  Haibo Wang

IPC: C12P17/08 ,  C12P17/04 ,  C12P7/44 ,  C12P7/42

Abstract: The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.

公开(公告)号：US12188068B2

公开(公告)日：2025-01-07

申请号：US17229543

申请日：2021-04-13

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Andreas W. Schirmer ,  Myong Ko ,  Haibo Wang

IPC: C12P17/08 ,  C12P7/42 ,  C12P7/44 ,  C12P17/04

Abstract: The present disclosure relates to chemo-enzymatic processes for the preparation of lactones (including, e.g., macrolactones, γ-lactones, and δ-lactones) and/or macrocyclic ketones, which are compounds of industrial value, for example, for use as fragrance ingredients. The chemo-enzymatic processes combine the in vivo microbial production of fatty acid derivatives and the subsequent ex vivo synthetic transformation of the fatty acid derivatives to provide the lactones and macrocyclic ketones.