公开(公告)号：US11981952B2

公开(公告)日：2024-05-14

申请号：US16915454

申请日：2020-06-29

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/6409 ,  C12N1/21 ,  C12N9/02 ,  C12N9/04 ,  C12N15/52 ,  C12N15/62 ,  C12P7/18 ,  C12P7/42 ,  C12P7/6436

CPC classification number: C12P7/6409 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0071 ,  C12N9/0077 ,  C12N15/52 ,  C12N15/62 ,  C12P7/18 ,  C12P7/42 ,  C12P7/6436 ,  C12Y114/14001 ,  C12Y114/15003 ,  C07K2319/00 ,  C12Y101/00 ,  C12Y102/01042 ,  Y02E50/10

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US10975402B2

公开(公告)日：2021-04-13

申请号：US16548545

申请日：2019-08-22

Applicant: GENOMATICA, INC.

Inventor： Jason J. Lutes ,  Stephen B. Del Cardayre

IPC: C12N1/20 ,  C12P13/02 ,  C12N9/18 ,  C12N9/10 ,  C12N15/70 ,  C12N9/16

Abstract: The disclosure relates to a recombinant microorganism engineered to express an enzyme which catalyzes the conversion of a primary amine and an acyl thioester to a fatty amide. The disclosure further encompasses a method of producing a fatty amide by culturing the recombinant microorganism in the presence of a carbon source.

公开(公告)号：US12188068B2

公开(公告)日：2025-01-07

申请号：US17229543

申请日：2021-04-13

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Andreas W. Schirmer ,  Myong Ko ,  Haibo Wang

IPC: C12P17/08 ,  C12P7/42 ,  C12P7/44 ,  C12P17/04

Abstract: The present disclosure relates to chemo-enzymatic processes for the preparation of lactones (including, e.g., macrolactones, γ-lactones, and δ-lactones) and/or macrocyclic ketones, which are compounds of industrial value, for example, for use as fragrance ingredients. The chemo-enzymatic processes combine the in vivo microbial production of fatty acid derivatives and the subsequent ex vivo synthetic transformation of the fatty acid derivatives to provide the lactones and macrocyclic ketones.

公开(公告)号：US11814660B2

公开(公告)日：2023-11-14

申请号：US17120586

申请日：2020-12-14

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Louis G. Hom

IPC: C12P13/00 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/00 ,  C12N9/06

CPC classification number: C12P13/001 ,  C12N9/0008 ,  C12N9/0014 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/93 ,  C12Y102/01 ,  C12Y102/01042 ,  C12Y104/09001 ,  C12Y206/01019 ,  C12Y206/01082 ,  C12Y301/02 ,  C12Y602/01003

Abstract: The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof. Further contemplated are cultured recombinant host cells as well as methods of producing fatty amines by employing these host cells.

公开(公告)号：US11008597B2

公开(公告)日：2021-05-18

申请号：US15301754

申请日：2015-04-10

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Andreas W. Schirmer ,  Myong Ko ,  Haibo Wang

IPC: C12P17/08 ,  C12P17/04 ,  C12P7/44 ,  C12P7/42

Abstract: The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.

公开(公告)号：US10900057B2

公开(公告)日：2021-01-26

申请号：US15039052

申请日：2014-12-05

Applicant: Genomatica, Inc.

Inventor： Stephen B. Del Cardayre ,  Louis G. Hom

IPC: C12P13/00 ,  C12N9/16 ,  C12N9/02 ,  C12N9/10 ,  C12N9/00 ,  C12N9/06

Abstract: The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof. Further contemplated are cultured recombinant host cells as well as methods of producing fatty amines by employing these host cells.

公开(公告)号：US20210071212A1

公开(公告)日：2021-03-11

申请号：US16915454

申请日：2020-06-29

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/64 ,  C12N9/02 ,  C12P7/42 ,  C12N15/62 ,  C12P7/18 ,  C12N15/52 ,  C12N9/04

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US10711288B2

公开(公告)日：2020-07-14

申请号：US14897285

申请日：2014-06-16

Applicant: GENOMATICA, INC.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/64 ,  C12N1/21 ,  C12N9/04 ,  C12N9/02 ,  C12N9/88 ,  C12N9/10 ,  C12N9/06 ,  C12N15/53 ,  C12N15/54 ,  C12N9/60 ,  C07K19/00 ,  C12P7/42 ,  C12N15/62 ,  C12P7/18 ,  C12N15/52

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.