公开(公告)号：US20220002356A1

公开(公告)日：2022-01-06

申请号：US17271442

申请日：2019-08-29

Applicant: Genomatica, Inc.

Inventor： Stephen Thomas PAYNE ,  Scott Allen FRYKMAN ,  Bernardo Moura Torres DA COSTA ,  Isolde CALLIHAN ,  Sankaranarayanan VENKITESWARAN ,  Leland Ken WONG

IPC: C07K14/245 ,  C12P7/64 ,  C12N1/22 ,  C12N9/02 ,  C12N9/06 ,  C12N9/10 ,  C12N9/18

Abstract: The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids and fatty acid derivatives from cellulosic biomass, xylose, and/or a glucose/xylose mix by employing the host cells expressing the engineered XylR variants and compositions of biologically produced fatty acids and fatty acid derivatives.