公开(公告)号：US20200087643A1

公开(公告)日：2020-03-19

申请号：US16616872

申请日：2018-05-25

Applicant: Genovis AB

Inventor： Fredrik Leo ,  Rolf Lood ,  Stephan Bjork ,  Malin Mejare ,  Fredrik Olsson

IPC: C12N9/24 ,  C12N9/52 ,  G01N33/84

Abstract: The present invention relates to enzymes and combinations thereof useful for studying glycoproteins, and corresponding methods of use. In particular, the invention relates to a sialidase composition comprising an additional protease and/or glycosidase, preferably an O-glycoprotein-specific endoprotease and/or an O-glycosidase.

公开(公告)号：US11584922B2

公开(公告)日：2023-02-21

申请号：US16616827

申请日：2018-05-25

Applicant: Genovis AB

Inventor： Fredrik Leo ,  Rolf Lood ,  Stephan Bjork ,  Malin Mejare ,  Fredrik Olsson

IPC: C12N9/24 ,  C12N9/52 ,  G01N33/84 ,  G01N33/68

Abstract: The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.

公开(公告)号：US20230212543A1

公开(公告)日：2023-07-06

申请号：US18145807

申请日：2022-12-22

Applicant: Genovis AB

Inventor： Fredrik Leo ,  Rolf Lood ,  Stephan Bjork ,  Malin Mejare ,  Fredrik Olsson

IPC: C12N9/52 ,  G01N33/68

CPC classification number: C12N9/52 ,  G01N33/68

Abstract: The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.

公开(公告)号：US20200172889A1

公开(公告)日：2020-06-04

申请号：US16616827

申请日：2018-05-25

Applicant: Genovis AB

Inventor： Fredrik Leo ,  Rolf Lood ,  Stephan Bjork ,  Malin Mejare ,  Fredrik Olsson

IPC: C12N9/52 ,  C12N9/24 ,  G01N33/68

Abstract: The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.