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公开(公告)号：US20200087643A1
公开(公告)日：2020-03-19
申请号：US16616872
申请日：2018-05-25
Applicant: Genovis AB
Inventor： Fredrik Leo , Rolf Lood , Stephan Bjork , Malin Mejare , Fredrik Olsson
Abstract: The present invention relates to enzymes and combinations thereof useful for studying glycoproteins, and corresponding methods of use. In particular, the invention relates to a sialidase composition comprising an additional protease and/or glycosidase, preferably an O-glycoprotein-specific endoprotease and/or an O-glycosidase.
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公开(公告)号：US20160252521A1
公开(公告)日：2016-09-01
申请号：US15030367
申请日：2014-10-17
Applicant: GENOVIS AB
Inventor： Fredrik OLSSON , Stephen Georg BJOK , Maria NORDGREN , Sarah FREDRIKSSON
IPC: G01N33/68
CPC classification number: G01N33/6857 , G01N2333/924
Abstract: The present invention relates to methods for analysing molecules comprising immunoglobulin Fc regions for the presence or absence of high-mannose glycans, and to for carrying out such methods.
Abstract translation: 本发明涉及用于分析包含免疫球蛋白Fc区域用于存在或不存在高甘露糖聚糖的分子的方法，以及用于进行这些方法。
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公开(公告)号：US20230212543A1
公开(公告)日：2023-07-06
申请号：US18145807
申请日：2022-12-22
Applicant: Genovis AB
Inventor： Fredrik Leo , Rolf Lood , Stephan Bjork , Malin Mejare , Fredrik Olsson
Abstract: The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.
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公开(公告)号：US20200172889A1
公开(公告)日：2020-06-04
申请号：US16616827
申请日：2018-05-25
Applicant: Genovis AB
Inventor： Fredrik Leo , Rolf Lood , Stephan Bjork , Malin Mejare , Fredrik Olsson
Abstract: The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.
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Patent Agency Ranking
公开(公告)号：US20170242032A1
公开(公告)日：2017-08-24
申请号：US15512505
申请日：2015-09-22
Applicant: GENOVIS AB
Inventor： Sarah FREDRIKSSON , Magdalena Widgren Sandberg , Fredrik Olsson
IPC: G01N33/68
CPC classification number: G01N33/6854 , C12Q1/37 , G01N2333/315 , G01N2333/952
Abstract: The invention provides methods for analysing a sample of immunoglobulins to determine the amount of IgG aggregates present in the sample.
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公开(公告)号：US12006530B2
公开(公告)日：2024-06-11
申请号：US16075059
申请日：2017-02-03
Applicant: GENOVIS AB
Inventor： Ulrich Von Pawel-Rammingen , Christian Spoerry
CPC classification number: C12Q1/37 , C12N9/641 , G01N33/6854
Abstract: The invention relates to new Streptococcal proteases designated IgdE which display IgG degrading cysteine protease activity. The invention further relates to in vitro methods of cleaving IgG using the described Streptococcal proteases, using the methods to generate Fc and Fab fragments, and using the methods to detect IgG.
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公开(公告)号：US20230399684A1
公开(公告)日：2023-12-14
申请号：US18034338
申请日：2021-10-19
Applicant: Genovis AB
Inventor： Ola S¿derberg , Leonie Wenson , Bjõrn Hellman , Erik Bivehed , Johan Heldin
IPC: C12Q1/6844 , C12N9/12
CPC classification number: C12Q1/6844 , C12N9/1252 , C12Y207/07007
Abstract: The disclosure relates to a recombinant DNA dependent DNA polymerase having 5′-3′ exonuclease activity and lacking 3′-5′ exonuclease activity, wherein said polymerase is capable of extending DNA polymerisation from a single mismatched base pair and has an error rate of at least 1:1000. The disclosure further relates to a nucleic acid molecule encoding the recombinant DNA dependent DNA polymerase, a method for synthesizing double stranded DNA (dsDNA), a method for obtaining the position of a single strand break in a template dsDNA molecule, a method to introduce mutations in DNA of bacterial or eukaryotic cells, or organisms.
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公开(公告)号：US11584922B2
公开(公告)日：2023-02-21
申请号：US16616827
申请日：2018-05-25
Applicant: Genovis AB
Inventor： Fredrik Leo , Rolf Lood , Stephan Bjork , Malin Mejare , Fredrik Olsson
Abstract: The present invention relates to a novel endoprotease, mutants thereof having binding but lacking or having reduced hydrolyzing activity, and use in methods of studying and isolating O-linked glycoproteins.
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公开(公告)号：US20160231329A1
公开(公告)日：2016-08-11
申请号：US15023042
申请日：2014-09-18
Applicant: GENOVIS AB
Inventor： Fredrik OLSSON , Maria NORDGREN , Malin MEJARE , Sarah FREDRIKSSON
CPC classification number: G01N33/6857 , C07K16/00 , C07K2317/53 , C12N9/6472 , C12Y304/2201 , G01N33/6854 , G01N2333/96413
Abstract: The inventions provides methods for analysing a sample of immunoglobulins, related peptides, and kits for carrying out such methods.
Abstract translation: 本发明提供了用于分析免疫球蛋白样品，相关肽和用于进行这些方法的试剂盒的方法。
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