公开(公告)号：US20210393590A1

公开(公告)日：2021-12-23

申请号：US17465994

申请日：2021-09-03

Applicant: Genzyme Corporation

Inventor： Hanlan LIU ,  Chris WILLIS ,  Renu BHARDWAJ ,  Diane P. COPELAND ,  Abizer HARIANAWALA ,  Jeffrey SKELL ,  John MARSHALL ,  Jianmei KOCHLING ,  Gerard PALACE ,  Judith PETERSCHMITT ,  Craig SIEGEL ,  Seng CHENG

IPC: A61K31/4025 ,  C07D405/06 ,  C07D319/16 ,  A61K45/06

Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula 1 Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.

公开(公告)号：US20210369672A1

公开(公告)日：2021-12-02

申请号：US17143821

申请日：2021-01-07

Applicant: Genzyme Corporation

Inventor： Hanlan LIU ,  Chris WILLIS ,  Renu BHARDWAJ ,  Diane P. COPELAND ,  Abizer HARIANAWALA ,  Jeffrey SKELL ,  John MARSHALL ,  Jianmei KOCHLING ,  Gerard PALACE ,  Judith PETERSCHMITT ,  Craig SIEGEL ,  Seng CHENG

IPC: A61K31/4025 ,  C07D405/06 ,  A61K45/06 ,  C07D319/16

Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.