公开(公告)号：US20240002374A1

公开(公告)日：2024-01-04

申请号：US17742169

申请日：2022-05-11

申请人： Genzyme Corporation

发明人： Junkai Liao ,  Mark Munson ,  Zhongli Gao ,  Gregory Hurlbut ,  Sylvie Baltzer ,  Bertrand Vivet ,  Brian Freed ,  Hans Peter Nestler ,  Helen Yeoman ,  Ingrid Mechin ,  Martin Smrcina ,  Nina Ma ,  Sylvain Lebreton ,  Ryan Hartung ,  William Wire ,  Sukanthini Thurairatnam

IPC分类号： C07D417/12 ,  C07D277/52 ,  C07D417/04 ,  C07D417/14 ,  C07F9/22 ,  C07D498/10

CPC分类号： C07D417/12 ,  C07D277/52 ,  C07D498/10 ,  C07D417/14 ,  C07F9/222 ,  C07D417/04

摘要： The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.