公开(公告)号：US4981786A

公开(公告)日：1991-01-01

申请号：US094176

申请日：1987-09-04

申请人： Geoffrey A. Dafforn ,  Nurith Kurn ,  Martin Becker ,  Edwin F. Ullman

发明人： Geoffrey A. Dafforn ,  Nurith Kurn ,  Martin Becker ,  Edwin F. Ullman

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/558 ,  G01N37/00

CPC分类号： G01N33/558 ,  B01L3/5023 ,  G01N33/5302 ,  G01N33/54366 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S436/81

摘要： A device is disclosed for conducting an assay. The device comprises a housing, means enclosed in the housing for capturing a first member of a specific binding pair (sbp) in a zone and for allowing liquid to be transported by capillary action away from the zone, first means in the housing for introducing the sample into the device, and second means in the housing other than the first means for introducing a liquid reagent other than the sample into the device. The device of the invention finds use in assay methods for the determination of an analyte in a sample suspected of containing the analyte. Kits for conducting an assay are also disclosed.

公开(公告)号：US08143001B2

公开(公告)日：2012-03-27

申请号：US11948784

申请日：2007-11-30

申请人： Nurith Kurn ,  Geoffrey A. Dafforn

发明人： Nurith Kurn ,  Geoffrey A. Dafforn

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6827 ,  C12P19/34 ,  C12Q2525/119 ,  C12Q2521/531

摘要： The invention relates to methods for analysis of nucleic acid methylation status, and fragmentation and/or labeling and/or immobilization of nucleic acids. More particularly, the invention relates to methods for fragmentation and/or labeling and/or immobilization of nucleic acids comprising labeling and/or cleavage and/or immobilization at abasic sites.

摘要翻译： 本发明涉及用于分析核酸甲基化状态以及核酸的断裂和/或标记和/或固定化的方法。 更具体地说，本发明涉及核酸的分离和/或标记和/或固定化的方法，包括在非碱性位点标记和/或切割和/或固定化。

公开(公告)号：US20090233804A1

公开(公告)日：2009-09-17

申请号：US11948784

申请日：2007-11-30

申请人： Nurith Kurn ,  Geoffrey A. Dafforn

发明人： Nurith Kurn ,  Geoffrey A. Dafforn

IPC分类号： C40B30/04 ,  C12P19/34 ,  C12Q1/68 ,  C40B50/00

CPC分类号： C12Q1/6827 ,  C12P19/34 ,  C12Q2525/119 ,  C12Q2521/531

摘要： The invention relates to methods for analysis of nucleic acid methylation status, and fragmentation and/or labeling and/or immobilization of nucleic acids. More particularly, the invention relates to methods for fragmentation and/or labeling and/or immobilization of nucleic acids comprising labeling and/or cleavage and/or immobilization at abasic sites.

摘要翻译： 本发明涉及用于分析核酸甲基化状态以及核酸的断裂和/或标记和/或固定化的方法。 更具体地说，本发明涉及核酸的分离和/或标记和/或固定化的方法，包括在非碱性位点标记和/或切割和/或固定化。