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    Multiparticulates
    2.
    发明申请
    Multiparticulates 有权
    多粒体

    公开(公告)号：US20080260815A1

    公开(公告)日：2008-10-23

    申请号：US11661478

    申请日：2005-08-31

    申请人： Geoffrey Gerard Hayes ,  Vincenzo Martinelli ,  Hassan Mohammad ,  Harjit Tamber ,  Malcolm Walden ,  Steve Whitelock

    发明人： Geoffrey Gerard Hayes ,  Vincenzo Martinelli ,  Hassan Mohammad ,  Harjit Tamber ,  Malcolm Walden ,  Steve Whitelock

    IPC分类号： A61K9/66 ,  A61K9/14

    CPC分类号： B29C47/60 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1635 ,  A61K31/485 ,  B29C47/0011 ,  B29C47/6093

    摘要： Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticising excipient in an amount sufficient to act as plasticiser and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticising excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.

    摘要翻译： 含有药物活性剂的混合物的挤出可以使用足够作为增塑剂的量的增塑赋形剂实现，并且还用作润滑剂，从而避免包含润滑剂的需要。 本发明提供了具有控制释放特性的多颗粒，基本上不含润滑剂。 本发明优选地涉及包含阿片样物质如挤压的多颗粒，例如羟考酮，甲基丙烯酸铵共聚物，例如RSPO，增塑赋形剂如优选硬脂醇，以及水分渗透性改进剂，例如优选RLPO。 所获得的多颗粒显示出与pH无关的释放速率分布。