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公开(公告)号：US20050191352A1
公开(公告)日：2005-09-01
申请号：US11056035
申请日：2005-02-11
申请人： Geoffrey Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
CPC分类号： A61K9/1635 , A61K9/16 , A61K9/1694 , Y10T428/2982
摘要： The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
摘要翻译： 本发明涉及一种使用熔体挤出机制备控释药物挤出物的方法，其中熔融挤出机包括支撑孔的模头和与模头相邻的切割器，其中 挤出的混合物在压力下出现时会切割挤出的混合物，并仍然从模板的孔口熔化或软化。
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公开(公告)号：US20060165790A1
公开(公告)日：2006-07-27
申请号：US11314464
申请日：2005-12-20
申请人： Malcolm Walden , Geoffrey Hayes , Hassan Mohammad , Harjit Tamber , Steve Whitelock , Vincenzo Martinelli
发明人： Malcolm Walden , Geoffrey Hayes , Hassan Mohammad , Harjit Tamber , Steve Whitelock , Vincenzo Martinelli
IPC分类号： A61K31/485 , A61K9/22
CPC分类号： A61K9/1635 , A61K9/4808 , A61K31/485
摘要： Multipartulates of oxycodone can be made by extrusion of a blend which suitably contains (a) oxycodone, (b) water-insoluble ammonium methacrylate copolymer, (c) plasticiser, (d) lubricant and (e) water permeability modifier.
摘要翻译： 羟考酮的多部分可以通过挤出适合含有（a）羟考酮，（b）水不溶性甲基丙烯酸铵共聚物，（c）增塑剂，（d）润滑剂和（e）水渗透性改性剂）的共混物来制备。
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公开(公告)号：US20080260815A1
公开(公告)日：2008-10-23
申请号：US11661478
申请日：2005-08-31
申请人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Harjit Tamber , Malcolm Walden , Steve Whitelock
CPC分类号： B29C47/60 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1635 , A61K31/485 , B29C47/0011 , B29C47/6093
摘要： Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticising excipient in an amount sufficient to act as plasticiser and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticising excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.
摘要翻译： 含有药物活性剂的混合物的挤出可以使用足够作为增塑剂的量的增塑赋形剂实现，并且还用作润滑剂，从而避免包含润滑剂的需要。 本发明提供了具有控制释放特性的多颗粒，基本上不含润滑剂。 本发明优选地涉及包含阿片样物质如挤压的多颗粒，例如羟考酮，甲基丙烯酸铵共聚物，例如RSPO，增塑赋形剂如优选硬脂醇，以及水分渗透性改进剂，例如优选RLPO。 所获得的多颗粒显示出与pH无关的释放速率分布。
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公开(公告)号：US09603802B2
公开(公告)日：2017-03-28
申请号：US12241650
申请日：2008-09-30
申请人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
IPC分类号： A61K9/16
CPC分类号： A61K9/1635 , A61K9/16 , A61K9/1694 , Y10T428/2982
摘要： The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
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公开(公告)号：US09259872B2
公开(公告)日：2016-02-16
申请号：US11661478
申请日：2005-08-31
申请人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Harjit Tamber , Malcolm Walden , Steve Whitelock
CPC分类号： B29C47/60 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1635 , A61K31/485 , B29C47/0011 , B29C47/6093
摘要： Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticizing excipient in an amount sufficient to act as plasticizer and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticizing excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.
摘要翻译： 含有药物活性剂的混合物的挤出可以使用足够充当增塑剂的量的增塑赋形剂实现，并且还用作润滑剂，从而避免包含润滑剂的需要。 本发明提供了具有控制释放特性的多颗粒，基本上不含润滑剂。 本发明优选针对含有阿片样物质如氢可酮，甲基丙烯酸铵共聚物（如RS-RSPO），增塑赋形剂如硬脂醇和水溶性改良剂（例如优选RLPO）的挤出多颗粒。 所获得的多颗粒显示出与pH无关的释放速率分布。
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公开(公告)号：US20090029170A1
公开(公告)日：2009-01-29
申请号：US12241650
申请日：2008-09-30
申请人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Gerard Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Allan Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
CPC分类号： A61K9/1635 , A61K9/16 , A61K9/1694 , Y10T428/2982
摘要： The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder,wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
摘要翻译： 本发明涉及一种使用熔体挤出机制备控释药物挤出物的方法，其中熔融挤出机包括支撑孔的模头和与模头相邻的切割器，其中 挤出的混合物在压力下出现时会切割挤出的混合物，并仍然从模板的孔口熔化或软化。
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